There is evidence that excessive stress exposure of the brain, mediated through the
neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain …

Animal studies on the effects of chronic variable stress during the peripubertaljuvenile
period on hippocampal structure and function are lacking. Twentyeightdayold Sprague …

For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …

Studies of early life stress (ELS) demonstrate the long-lasting effects of acute and chronic
stress on developmental trajectories. Such experiences can become biologically …

Early-life adversity (ELA) is one of the major risk factors for serious mental and physical
health risks later in life. ELA has been associated with dysfunctional neurodevelopment …

Uncontrollable stress has been recognized to influence the hippocampus at various levels of
analysis. Behaviorally, human and animal studies have found that stress generally impairs …

Background Opportunities for research on the causes and consequences of stress-related
hippocampal atrophy are limited in human psychiatric disorders. Therefore, this longitudinal …

Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

It has become increasingly clear that the increase in corticosteroid levels, eg after a brief
stressor induce molecular and cellular changes in brain, including the hippocampal …

Early life stress is a well-documented risk factor for the development of psychopathology in
genetically predisposed individuals. As it is hard to study how early life stress impacts …