Anxiolytic effects of nicotine in zebrafish

ED Levin, Z Bencan, DT Cerutti - Physiology & behavior, 2007 - Elsevier
Anxiolytic effects of nicotine have been documented in studies with rodents and humans.
Understanding the neural basis of nicotine-induced anxiolysis can help both with …

The role of α7 and α4β2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish

Z Bencan, ED Levin - Physiology & behavior, 2008 - Elsevier
Zebrafish (Danio rerio) have been widely used to study the molecular mechanisms of
development including neurodevelopment. More recently, they have begun to be used to …

Zebrafish for the study of the biological effects of nicotine

EW Klee, JO Ebbert, H Schneider… - Nicotine & Tobacco …, 2011 - academic.oup.com
Introduction: Zebrafish are emerging as a powerful animal model for studying the molecular
and physiological effects of nicotine exposure. The zebrafish have many advantageous …

Timing of nicotine effects on learning in zebrafish

ED Levin, J Limpuangthip, T Rachakonda… - …, 2006 - Springer
Rationale Nicotine has been shown in many, but not all, studies to improve cognitive
function in a number of species including rats, mice, monkeys, and humans. Recently, we …

Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development

ED Levin - 2011 - degruyter.com
Zebrafish can provide a valuable animal model to screen potential cognitive enhancing and
anxiolytic drugs. They are economical and can provide a relatively quick indication of …

Nicotine effects on learning in zebrafish: the role of dopaminergic systems

D Eddins, A Petro, P Williams, DT Cerutti… - Psychopharmacology, 2009 - Springer
Rationale Nicotine improves cognitive function in a number of animal models including rats,
mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and …

Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety

Z Bencan, D Sledge, ED Levin - Pharmacology Biochemistry and Behavior, 2009 - Elsevier
Zebrafish are becoming more widely used to study neurobehavioral pharmacology. We
have developed a method to assess novel environment diving behavior of zebrafish as a …

Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders

MG Kutlu, TJ Gould - Biochemical pharmacology, 2015 - Elsevier
Anxiety disorders are a group of crippling mental diseases affecting millions of Americans
with a 30% lifetime prevalence and costs associated with healthcare of $42.3 billion. While …

Nicotinic involvement in memory function in zebrafish

ED Levin, E Chen - Neurotoxicology and teratology, 2004 - Elsevier
Zebrafish are an emerging model for the study of the molecular mechanisms of brain
function. To conduct studies of the neural bases of behavior in zebrafish, we must …

Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice

BJ Caldarone, SL King, MR Picciotto - Neuroscience letters, 2008 - Elsevier
Smoking appears to increase overall levels of stress, despite self-reports that men and
women smoke to control symptoms of anxiety. The overall incidence of anxiety disorders is …