The liver produces and stores various nutrients that are necessary for the body and serves
as a chemical plant, metabolizing carbohydrates, fats, hormones, vitamins, and minerals. It is …

Various hepatic models are currently used as in vitro models alternative to in vivo animal
studies for toxicity assessment. Most of these models including the in vivo animal models are …

The 3D cell culture model is an indispensable tool in the study of liver biology in the field of
health and disease and the development of clinically relevant products for liver therapies …

As the primary site for the biotransformation of drugs, the liver is the most focused on organ
type in pharmaceutical research. However, despite being widely used in pharmaceutical …

The liver is a vital organ fulfilling a central role in over 500 major metabolic functions,
including serving as the most essential site for drug biotransformation. Dysfunction of the …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

Abstract Background: Three-dimensional (3D) cell cultures with architectural and
biomechanical properties similar to those of natural tissue have been the focus for …

Recent research has shown that the maintenance of relevant liver functions ex vivo requires
models in which the cells exhibit an in vivolike phenotype, often achieved by reconstitution …

Primary cultures of human hepatocytes are a reference cellular model, because they
maintain key features of liver cells in vivo, such as expression of drug-metabolizing …

The liver is one of the most complex organs in the body, performing a multitude of functions.
Liver tissue engineering is a combination of various strategies that aim at generating …