In order to investigate [11 C] nicotine binding and metabolism in the living human brain by
PET, routine protocols were developed for the preparation and purification of (S)-and (R)-[11 …

抄録 A nicotine agonist, 11 C-labeled (S)-nicotine, was synthesized by N-methylation of (S)-
nornicotine with [11 C]-methyl iodide in dimethylformamide-dimethylsulfoxide in order to …

Abstract (S)-and (R)-[11 C] nicotine were synthesized by methylation of (S)-and (R)-
nornicotine using [11 C] methyl iodide. Following their intravenous injection in tracer doses …

In order to study “in vivo” the distribution kinetics of (-)-nicotine in animals, this molecule was
labeled with carbon-11. Two synthesis methods are described. Immediately after …

This study assessed the in vivo distribution of 11C-nicotine and the absorbed radiation dose
from whole-body 11C-nicotine PET imaging of 11 healthy (5 male and 6 female) subjects …

Results: We found tissue pharmacokineticsof (Ft)-and (S)-[11C] nic-otine are adequately
described by the two-compartment model.(S)-nicotine challenge induced small but …

Since the brain is the major site of pharmacological activity of nicotine, it was of interest to
investigate the metabolism of nicotine by this organ. We now report our findings using …

Summary N-[methyl-11 C] nicotine (11 C-nicotine) was given intravenously to monkeys and
the uptake and regional distribution of radioactivity was followed in the brain using positron …

In the middle of the sixteenth century, tobacco (Nicotiana tabacum) was brought from
Portugal to France by the French ambassador Jean Nicot who gave it to the Queen …

Whole body autoradiograms of mice injected intravenously with ()nicotinemethylC14
show an initial accumulation of radioactivity in the CNS. This high concentration of nicotine …