Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
RG Pertwee - Life sciences, 2005 - Elsevier
There are at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled.
CB1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …
CB1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …
Pharmacology of cannabinoid CB1 and CB2 receptors
RG Pertwee - Pharmacology & therapeutics, 1997 - Elsevier
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …
Cannabinoid receptors and their ligands
RG Pertwee, RA Ross - … , Leukotrienes and Essential Fatty Acids (PLEFA), 2002 - Elsevier
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G
proteins. CB1 receptors exist primarily on central and peripheral neurons, one of their …
proteins. CB1 receptors exist primarily on central and peripheral neurons, one of their …
Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis
DR Janero, A Makriyannis - Expert opinion on emerging drugs, 2009 - Taylor & Francis
The endogenous cannabinoid (CB)(endocannabinoid) signaling system is involved in a
variety of (patho) physiological processes, primarily by virtue of natural, arachidonic acid …
variety of (patho) physiological processes, primarily by virtue of natural, arachidonic acid …
Molecular aspects of cannabinoid receptors
LA Matsuda - Critical Reviews™ in Neurobiology, 1997 - dl.begellhouse.com
Two cannabinoid receptors are reviewed with regard to their primary structure, ligand-
binding properties, and signal transduction systems. Both receptors have been cloned; …
binding properties, and signal transduction systems. Both receptors have been cloned; …
Recent advances in the development of selective ligands for the cannabinoid CB2 receptor
JW Huffman, KSC Marriott - Current topics in medicinal …, 2008 - ingentaconnect.com
Two subtypes of the mammalian cannabinoid receptor have been identified and
successfully cloned since 1990. The CB1 receptor is primarily located in the central nervous …
successfully cloned since 1990. The CB1 receptor is primarily located in the central nervous …
Cannabinoid signalling
DG Demuth, A Molleman - Life sciences, 2006 - Elsevier
After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …
Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
RG Pertwee - Current medicinal chemistry, 2010 - ingentaconnect.com
It is widely accepted that non-endogenous compounds that target CB1 and/or CB2 receptors
possess therapeutic potential for the clinical management of an ever growing number of …
possess therapeutic potential for the clinical management of an ever growing number of …
Pharmacological selection of cannabinoid receptor effectors: Signalling, allosteric modulation and bias
The type-1 cannabinoid receptor (CB 1) is a promising drug target for a wide range of
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …
diseases. However, many existing and novel candidate ligands for CB 1 have shown only …
Actions and regulation of ionotropic cannabinoid receptors
Almost three decades have passed since the identification of the two specific metabotropic
receptors mediating cannabinoid pharmacology. Thereafter, many cannabinoid effects, both …
receptors mediating cannabinoid pharmacology. Thereafter, many cannabinoid effects, both …