lncRNA recruits RNAi and the exosome to dynamically regulate pho1 expression in response to phosphate levels in fission yeast

S Shah, S Wittmann, C Kilchert… - Genes & …, 2014 - genesdev.cshlp.org
Numerous noncoding transcripts of unknown function have recently been identified. In this
study, we report a novel mechanism that relies on transcription of noncoding RNA prt (pho1 …

Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression …

D Chatterjee, AM Sanchez, Y Goldgur, S Shuman… - Rna, 2016 - rnajournal.cshlp.org
Expression of fission yeast Pho1 acid phosphatase is repressed during growth in phosphate-
rich medium. Repression is mediated by transcription of the prt locus upstream of pho1 to …

A long noncoding (lnc) RNA governs expression of the phosphate transporter Pho84 in fission yeast and has cascading effects on the flanking prt lncRNA and pho1 …

A Garg, AM Sanchez, S Shuman, B Schwer - Journal of Biological …, 2018 - ASBMB
The expression of the phosphate transporter Pho84 in fission yeast Schizosaccharomyces
pombe is repressed in phosphate-rich medium and induced during phosphate starvation …

Genetic screen for suppression of transcriptional interference reveals fission yeast 14–3–3 protein Rad24 as an antagonist of precocious Pol2 transcription termination

A Garg, S Shuman, B Schwer - Nucleic Acids Research, 2022 - academic.oup.com
Expression of fission yeast Pho1 acid phosphatase is repressed under phosphate-replete
conditions by transcription of an upstream prt lncRNA that interferes with the pho1 mRNA …

A role for noncoding transcription in activation of the yeast PHO5 gene

JP Uhler, C Hertel, JQ Svejstrup - Proceedings of the …, 2007 - National Acad Sciences
Noncoding, or intergenic, transcription by RNA polymerase II (RNAPII) is remarkably
widespread in eukaryotic organisms, but the effects of such transcription remain poorly …

Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination

AM Sanchez, A Garg, B Schwer, S Shuman - RNA, 2023 - rnajournal.cshlp.org
Fission yeast phosphate homeostasis gene pho1 is actively repressed during growth in
phosphate-rich medium by transcription in cis of a long noncoding (lnc) RNA from the 5 …

Poly (A) site choice and Pol2 CTD Serine-5 status govern lncRNA control of phosphate-responsive tgp1 gene expression in fission yeast

AM Sanchez, S Shuman, B Schwer - RNA, 2018 - rnajournal.cshlp.org
Expression of fission yeast glycerophosphate transporter Tgp1 is repressed in phosphate-
rich medium and induced during phosphate starvation. Repression is enforced by …

Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast

SR Atkinson, S Marguerat, DA Bitton… - Rna, 2018 - rnajournal.cshlp.org
Long noncoding RNAs (lncRNAs), which are longer than 200 nucleotides but often unstable,
contribute a substantial and diverse portion to pervasive noncoding transcriptomes. Most …

Nutrient-regulated antisense and intragenic RNAs modulate a signal transduction pathway in yeast

M Nishizawa, T Komai, Y Katou, K Shirahige, T Ito… - PLoS …, 2008 - journals.plos.org
The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response
to a change in nutrient availability. The PHO system is a well-studied case in the …

A scaffold lncRNA shapes the mitosis to meiosis switch

V Andric, A Nevers, D Hazra, S Auxilien… - Nature …, 2021 - nature.com
Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in
response to intra-or extracellular signals but the underlying molecular mechanisms remain …