Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …

For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and
glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular …

Low-grade gliomas represent the most frequent brain tumors arising during childhood. They
are characterized by a broad and heterogeneous group of tumors that are currently …

Despite the fact that they are not typically life-threatening, low-grade gliomas (LGGs) remain
a significant clinical challenge in pediatric neuro-oncology due to comorbidities associated …

Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …

As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in
pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve …

Brain tumors constitute the largest source of oncologic mortality in children and low-grade
gliomas are among most common pediatric central nervous system tumors. Pediatric low …

Gliomas in children differ from their adult counterparts by their distribution of histological
grade, site of presentation and rate of malignant transformation. Although rare in the …

High-grade pediatric central nervous system glial tumors are comprised primarily of
anaplastic astrocytomas (AA, WHO grade III) and glioblastomas (GBM, WHO grade IV). High …

High-grade gliomas in children are different from those that arise in adults. Recent
collaborative molecular analyses of these rare cancers have revealed previously …