Appetite suppression and weight loss after the cannabinoid antagonist SR 141716
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body
weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 …
weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 …
Cannabinoid (CB) 1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat
AP Chambers, KA Sharkey, HS Koopmans - Physiology & behavior, 2004 - Elsevier
Cannabinoid (CB) 1 receptors are present throughout the nervous system, including several
areas implicated in the control of food intake. Central and peripheral administration of CB1 …
areas implicated in the control of food intake. Central and peripheral administration of CB1 …
Antiobesity effects of chronic cannabinoid CB1 receptor antagonist treatment in diet-induced obese mice
AL Hildebrandt, DM Kelly-Sullivan, SC Black - European journal of …, 2003 - Elsevier
We determined the effect of a cannabinoid CB1 receptor antagonist (AM-251; N-(Piperidin-1-
yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) on food …
yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide) on food …
The cannabinoid CB1 antagonists SR 141716A and AM 251 suppress food intake and food-reinforced behavior in a variety of tasks in rats
PJ McLaughlin, K Winston, L Swezey… - Behavioural …, 2003 - journals.lww.com
Cannabinoid CB1 receptor agonists, including delta-9-tetrahydrocannabinol (Δ 9-THC)(the
main psychoactive ingredient in marijuana) have been shown to increase feeding in rats …
main psychoactive ingredient in marijuana) have been shown to increase feeding in rats …
Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
SP Vickers, LJ Webster, A Wyatt, CT Dourish… - …, 2003 - Springer
Rationale The selective CB 1 receptor antagonist, SR 141716, has been demonstrated to
reduce food consumption in a range of animal species. Objective To assess the effect of …
reduce food consumption in a range of animal species. Objective To assess the effect of …
Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH21, a peripherally acting neutral cannabinoid receptor antagonist, in …
The endogenous cannabinoid system plays an important modulatory role in feeding
behaviour and metabolism, acting at both central and peripheral levels. Chronic …
behaviour and metabolism, acting at both central and peripheral levels. Chronic …
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats
KS Sink, PJ McLaughlin, JAT Wood, C Brown… - …, 2008 - nature.com
Drugs that interfere with cannabinoid CB1 transmission suppress various food-motivated
behaviors, and it has been suggested that such drugs could be useful as appetite …
behaviors, and it has been suggested that such drugs could be useful as appetite …
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats
PJ McLaughlin, KM Winston, CL Limebeer… - …, 2005 - Springer
Rationale A growing body of evidence suggests that cannabinoid CB1 receptor antagonists
have potential therapeutic utility as appetite suppressants. However, the specific …
have potential therapeutic utility as appetite suppressants. However, the specific …
Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats
NE Rowland, M Mukherjee, K Robertson - Psychopharmacology, 2001 - Springer
Rationale: Recent studies in animals have implicated endogenous cannabinoids in the
regulation of palatable food intake, but it is not yet clear to what extent pharmacological …
regulation of palatable food intake, but it is not yet clear to what extent pharmacological …
Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats
ANA Verty, IS McGregor, PE Mallet - Neuroscience letters, 2004 - Elsevier
Administration of the CB1 receptor antagonist SR 141716 [N-piperidino-5-(4-chlorophenyl)-
1-(2, 4-dichlorophenyl)-4-methylpyrazole-3-carboxamide] suppresses intake of highly …
1-(2, 4-dichlorophenyl)-4-methylpyrazole-3-carboxamide] suppresses intake of highly …