Accumulating evidence suggests that stellate cells are involved in the regulation of the liver
microcirculation and portal hypertension. Activated hepatic stellate cells have the necessary …

Hepatic stellate cells have received considerable attention as key components of the
fibrogenic response to injury. Beyond this feature, they also have been implicated as …

Hepatic stellate cells (HSCs) are pericytes of liver in the space between parenchymal cells
and sinusoidal endothelial cells of the hepatic lobule. HSCs comprise specialized functions …

Introduction 3. Paracrine soluble factors regulating hepatic stellate cell activation 3.1.
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …

Hepatic stellate cells (HSCs), a mesenchymal cell type in hepatic parenchyma, have unique
features with respect to their cellular origin, morphology, and function. Normal, quiescent …

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver
physiology and fibrogenesis. They are located in the space of Disse and maintain close …

In the past 10 years we have witnessed an exponential increase in the knowledge on the
development and progression of liver fibrosis. At present, liver fibrogenesis is referred to as …

Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …

Connected with the intestinal tract through the portal circulation, liver sinusoids function as
the first line of defense against extrahepatic stimuli such as bacterial products and other …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …