Methylated circulating tumor DNA in hepatocellular carcinoma: A comprehensive analysis of biomarker potential and clinical implications

Q Zhu, J Xie, W Mei, C Zeng - Cancer Treatment Reviews, 2024 - Elsevier
The intricate epigenetic landscape of hepatocellular carcinoma (HCC) is profoundly
influenced by alterations in DNA methylation patterns. Understanding these alterations is …

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

R Xu, W Wei, M Krawczyk, W Wang, H Luo, K Flagg… - Nature materials, 2017 - nature.com
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …

Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors

T Draškovič, N Zidar, N Hauptman - Cancers, 2023 - mdpi.com
Simple Summary Malignant liver tumors consist of primary tumors and metastases. A correct
diagnosis can be achieved with different methods; one of them is the analysis of the cell-free …

Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction

FJ Nassar, ZS Msheik, RR Nasr, SN Temraz - Clinical Epigenetics, 2021 - Springer
Worldwide, colorectal cancer (CRC) is a deadly disease whose death rate ranks second
among cancers though its incidence ranks third. Early CRC detection is key and is …

Methylated ctDNA quantification: non-invasive approach to monitoring hepatocellular carcinoma burden

I Angeli-Pahim, A Chambers, S Duarte… - Journal of the …, 2023 - journals.lww.com
Background: Non-invasive, precision monitoring of hepatocellular carcinoma (HCC)
treatment efficacy would greatly facilitate personalized therapy and improve patient …

Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study

DZ Guo, A Huang, YC Wang, S Zhou… - Clinical and …, 2024 - Wiley Online Library
Background Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve
patient survival. We aimed to develop a bloodbased assay to aid in the diagnosis, detection …

Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …

[HTML][HTML] Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

RA Hlady, X Zhao, X Pan, JD Yang, F Ahmed… - Theranostics, 2019 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is growing in
incidence but treatment options remain limited, particularly for late stage disease. As liver …

Circulating tumor DNA methylation: a promising clinical tool for cancer diagnosis and management

B Wang, M Wang, Y Lin, J Zhao, H Gu… - Clinical Chemistry and …, 2024 - degruyter.com
Cancer continues to pose significant challenges to the medical community. Early detection,
accurate molecular profiling, and adequate assessment of treatment response are critical …

Evaluation of methylation biomarkers for detection of circulating tumor DNA and application to colorectal cancer

SM Mitchell, T Ho, GS Brown, RT Baker, ML Thomas… - Genes, 2016 - mdpi.com
Solid tumors shed DNA into circulation, and there is growing evidence that the detection of
circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease …