Methylated circulating tumor DNA in hepatocellular carcinoma: A comprehensive analysis of biomarker potential and clinical implications
Q Zhu, J Xie, W Mei, C Zeng - Cancer Treatment Reviews, 2024 - Elsevier
The intricate epigenetic landscape of hepatocellular carcinoma (HCC) is profoundly
influenced by alterations in DNA methylation patterns. Understanding these alterations is …
influenced by alterations in DNA methylation patterns. Understanding these alterations is …
Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma
R Xu, W Wei, M Krawczyk, W Wang, H Luo, K Flagg… - Nature materials, 2017 - nature.com
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …
Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors
T Draškovič, N Zidar, N Hauptman - Cancers, 2023 - mdpi.com
Simple Summary Malignant liver tumors consist of primary tumors and metastases. A correct
diagnosis can be achieved with different methods; one of them is the analysis of the cell-free …
diagnosis can be achieved with different methods; one of them is the analysis of the cell-free …
Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction
Worldwide, colorectal cancer (CRC) is a deadly disease whose death rate ranks second
among cancers though its incidence ranks third. Early CRC detection is key and is …
among cancers though its incidence ranks third. Early CRC detection is key and is …
Methylated ctDNA quantification: non-invasive approach to monitoring hepatocellular carcinoma burden
I Angeli-Pahim, A Chambers, S Duarte… - Journal of the …, 2023 - journals.lww.com
Background: Non-invasive, precision monitoring of hepatocellular carcinoma (HCC)
treatment efficacy would greatly facilitate personalized therapy and improve patient …
treatment efficacy would greatly facilitate personalized therapy and improve patient …
Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study
DZ Guo, A Huang, YC Wang, S Zhou… - Clinical and …, 2024 - Wiley Online Library
Background Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve
patient survival. We aimed to develop a bloodbased assay to aid in the diagnosis, detection …
patient survival. We aimed to develop a bloodbased assay to aid in the diagnosis, detection …
Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer
H Luo, Q Zhao, W Wei, L Zheng, S Yi, G Li… - Science translational …, 2020 - science.org
Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …
[HTML][HTML] Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA
Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is growing in
incidence but treatment options remain limited, particularly for late stage disease. As liver …
incidence but treatment options remain limited, particularly for late stage disease. As liver …
Circulating tumor DNA methylation: a promising clinical tool for cancer diagnosis and management
B Wang, M Wang, Y Lin, J Zhao, H Gu… - Clinical Chemistry and …, 2024 - degruyter.com
Cancer continues to pose significant challenges to the medical community. Early detection,
accurate molecular profiling, and adequate assessment of treatment response are critical …
accurate molecular profiling, and adequate assessment of treatment response are critical …
Evaluation of methylation biomarkers for detection of circulating tumor DNA and application to colorectal cancer
SM Mitchell, T Ho, GS Brown, RT Baker, ML Thomas… - Genes, 2016 - mdpi.com
Solid tumors shed DNA into circulation, and there is growing evidence that the detection of
circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease …
circulating tumor DNA (ctDNA) has broad clinical utility, including monitoring of disease …
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