Bone has the unique capacity to heal without the formation of a fibrous scar, likely because
several of the cellular and molecular processes governing bone healing recapitulate the …

Angiogenesis and bone formation are coupled during skeletal development and fracture
healing. This relationship, although known for some time, has not been properly explored …

Bone vasculature plays a vital role in bone development, remodeling and homeostasis. New
blood vessel formation is crucial during both primary bone development as well as fracture …

The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a
highly vascularised tissue reliant on the close spatial and temporal connection between …

Bone is a richly vascularized connective tissue. As the main source of oxygen, nutrients,
hormones, neurotransmitters and growth factors delivered to the bone cells, vasculature is …

Angiogenesis is a key component of bone repair. New blood vessels bring oxygen and
nutrients to the highly metabolically active regenerating callus and serve as a route for …

Bone regeneration has long been a major focus for tissue engineers and the importance of
vascularization to the bone regeneration process has been well documented. Over the past …

Bone regeneration is a complex process requiring highly orchestrated interactions between
different cells and signals to form new mineralized tissue. Blood vessels serve as a structural …

Bone tissue renewal can be outlined as a complicated mechanism centered on the
interaction between osteogenic and angiogenic events capable of leading to bone formation …

Despite major research efforts to elucidate mechanisms of non-union formation, failed
fracture healing remains a common complication in orthopedic surgery. Adequate …