Biological studies of post-traumatic stress disorder

RK Pitman, AM Rasmusson, KC Koenen… - nature Reviews …, 2012 - nature.com
Post-traumatic stress disorder (PTSD) is the only major mental disorder for which a cause is
considered to be known: that is, an event that involves threat to the physical integrity of …

Animal models in translational studies of PTSD

NP Daskalakis, R Yehuda, DM Diamond - Psychoneuroendocrinology, 2013 - Elsevier
Understanding the neurobiological mechanisms of post-traumatic stress disorder (PTSD) is
of vital importance for developing biomarkers and more effective pharmacotherapy for this …

Clinical relevance of biologic findings in PTSD

R Yehuda - Psychiatric Quarterly, 2002 - Springer
Posttraumatic stress disorder (PTSD) describes a syndrome in which a trauma survivor
experiences an inability to get the event out of his/her mind. The symptoms of PTSD were …

The neurobiology and neuroendocrinology of stress: Implications for post-traumatic stress disorder from a basic science perspective

BS McEwen - Psychiatric Clinics, 2002 - psych.theclinics.com
Traumatic stress can have long-lasting consequences for an individual and can result in
post-traumatic stress disorder (PTSD). In PTSD, the maladaptive reactivity and …

PTSD and stress sensitisation: A tale of brain and body: Part 1: Human studies

R Stam - Neuroscience & Biobehavioral Reviews, 2007 - Elsevier
Post-traumatic stress disorder (PTSD) is a chronic, debilitating psychiatric disorder that can
follow exposure to extreme stressful experiences. It is characterised by hyperarousal and …

Biomarkers in posttraumatic stress disorder: overview and implications for future research

U Schmidt, SF Kaltwasser, CT Wotjak - Disease markers, 2013 - Wiley Online Library
PTSD can develop in the aftermath of traumatic incidents like combat, sexual abuse, or life
threatening accidents. Unfortunately, there are still no biomarkers for this debilitating anxiety …

Psychobiologic research in post-traumatic stress disorder

SM Southwick, D Bremner, JH Krystal… - Psychiatric Clinics of …, 1994 - Elsevier
There is little doubt that post-traumatic stress disorder (PTSD) has deep neurobiologic roots
in the organism's response to danger. Animal and human research have both implicated …

Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder

E Vermetten, JD Bremner - Depression and anxiety, 2002 - Wiley Online Library
This paper follows the preclinical work on the effects of stress on neurobiological and
neuroendocrine systems and provides a comprehensive working model for understanding …

Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy

O Bonne, C Grillon, M Vythilingam… - Neuroscience & …, 2004 - Elsevier
Post-traumatic stress disorder (PTSD) is one of the few DSM-IV diagnoses contingent upon
a psychosocial stressor. In this context, there is an urgent need to acquire a better …

Neurobiology of posttraumatic stress disorder

DJ Newport, CB Nemeroff - Current opinion in neurobiology, 2000 - Elsevier
Recent advances on the neurobiology of posttraumatic stress disorder include: the utilization
of functional brain imaging; the incorporation of cross-system research including …