14.1 Background To improve the guideline development process and facilitate the explicit,
systematic and transparent formulation of recommendations from evidence, in 2007 WHO …

Systematic reviews are essential to produce trustworthy guidelines. To assess the body of
evidence included in a systematic review, the Grading of Recommendations Assessment …

Objectives Clear communication of systematic review findings will help readers and decision
makers. We built on previous work to develop an approach that improves the clarity of …

This article is the first of a series providing guidance for use of the Grading of
Recommendations Assessment, Development, and Evaluation (GRADE) system of rating …

E24 CMAJ| JANUARY 13, 2020| VOLUME 192| ISSUE 2 scenario could lead to early
adoption of an intervention that may expose patients to harm. A better option would have …

Abstract Background The World Health Organization (WHO), like many other organisations
around the world, has recognised the need to use more rigorous processes to ensure that …

Background Guidelines aim to support evidence-informed practice but are inconsistently
used without implementation strategies. Our prior scoping review revealed that guideline …

The certainty of the evidence for interventions is the certainty or confidence that the true
effect is within a particular range or relative to a threshold. In the new pyramid of evidence …

Abstract Background The World Health Organization (WHO), like many other organisations
around the world, has recognised the need to use more rigorous processes to ensure that …

Objectives Expert guideline panelists are sometimes reluctant to offer weak/conditional/
contingent recommendations. Grading of Recommendations Assessment, Development and …