Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
[HTML][HTML] Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders
Over the past decade, large-scale genetic studies have successfully identified hundreds of
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …
Single-cell multi-cohort dissection of the schizophrenia transcriptome
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …
and the development of more effective therapies. Here, we performed single-cell dissection …
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …
us uniquely human. The development of the brain is a highly complex process, and this …
BrainSeq: neurogenomics to drive novel target discovery for neuropsychiatric disorders
CR Schubert, P O'Donnell, J Quan, JR Wendland… - Neuron, 2015 - cell.com
We outline an ambitious project to characterize the genetic and epigenetic regulation of
multiple facets of transcription in distinct brain regions across the human lifespan in samples …
multiple facets of transcription in distinct brain regions across the human lifespan in samples …
Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice
JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain
Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants
Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …