We have examined neuroanatomical, biochemical and endocrine parameters and spatial
learning in mice lacking the β2 subunit of the nicotinic acetylcholine receptor (nAChR) …

The distribution of the neuronal nicotinic acetylcholine receptor subunit α4 (nAChRα4) in the
brains of young (2–4 months) or aged (24–28 months) CBA/J mice was examined using …

Activation of neuronal nicotinic acetylcholine receptors (nAChRs) has been shown to
maintain cognitive function following aging or the development of dementia. Nicotine and …

Nicotinic acetylcholine receptor (nAChRs) proteins and gene transcripts are already present
in human prenatal brain and spinal cord at 4–6 weeks gestation, and a clear age-related …

Effects of neonatal nicotine exposure on the development of nicotinic acetylcholine receptor
(nAChR) α2, α3, α4, α7, and β2 subunit mRNAs and the number of nAChR isoforms in rat …

The hippocampus, a key structure for learning and memory processes, receives an
important cholinergic innervation and is densely packed with a variety of nicotinic …

Impairment in cholinergic systems is a highly consistent finding in human dementia. Among
cholinergic markers, marked decreases in nicotine binding have been most consistently …

Human postmortem studies have reported decreases with age in high affinity nicotine
binding in brain. We investigated the effect of age on β2-containing nicotinic acetylcholine …

As neurodegenerative disorders are better characterized, the importance of genetic and
environmental interactions is becoming more evident. Among the neurodegenerative …

Adult hippocampal neurogenesis declines with age in parallel with decreased performance
on a variety of hippocampaldependent tasks. We measured the rate of cellular proliferation …