Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …

Phenotypic plasticity is essential to the immune system, yet the factors that shape it are not
fully understood. Here, we comprehensively analyze immune cell phenotypes including …

Our understanding of how cells form distinct tissues and organs and interact with each other
is limited. Recent single-cell RNA sequencing (scRNA-seq) analyses have described the …

The mammalian immune system implements a remarkably effective set of mechanisms for
fighting pathogens. Its main components are haematopoietic immune cells, including …

The immune system varies in cell types, states, and locations. The complex networks,
interactions, and responses of immune cells produce diverse cellular ecosystems composed …

INTRODUCTION Blood is the predominant source for molecular analyses in humans, both in
clinical and research settings, and is the target for many therapeutic strategies, emphasizing …

The immune system encompasses a large degree of phenotypic diversity and plasticity in its
cell types, and more is to be uncovered. We argue that large, multiomic datasets of single …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …

The blood and immune systems develop in parallel during early prenatal life. Waves of
hematopoiesis separated in anatomical space and time give rise to circulating and tissue …