Cross-tissue immune cell analysis reveals tissue-specific features in humans
C Domínguez Conde, C Xu, LB Jarvis, DB Rainbow… - Science, 2022 - science.org
Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
Mapping the developing human immune system across organs
Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …
prenatal organs but were limited in describing the developing immune system as a …
Multiplexed high-throughput immune cell imaging reveals molecular health-associated phenotypes
Phenotypic plasticity is essential to the immune system, yet the factors that shape it are not
fully understood. Here, we comprehensively analyze immune cell phenotypes including …
fully understood. Here, we comprehensively analyze immune cell phenotypes including …
Mapping cell types across human tissues
Z Liu, Z Zhang - Science, 2022 - science.org
Our understanding of how cells form distinct tissues and organs and interact with each other
is limited. Recent single-cell RNA sequencing (scRNA-seq) analyses have described the …
is limited. Recent single-cell RNA sequencing (scRNA-seq) analyses have described the …
Structural cells are key regulators of organ-specific immune responses
The mammalian immune system implements a remarkably effective set of mechanisms for
fighting pathogens. Its main components are haematopoietic immune cells, including …
fighting pathogens. Its main components are haematopoietic immune cells, including …
Single-cell transcriptomics to explore the immune system in health and disease
MJT Stubbington, O Rozenblatt-Rosen, A Regev… - Science, 2017 - science.org
The immune system varies in cell types, states, and locations. The complex networks,
interactions, and responses of immune cells produce diverse cellular ecosystems composed …
interactions, and responses of immune cells produce diverse cellular ecosystems composed …
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
INTRODUCTION Blood is the predominant source for molecular analyses in humans, both in
clinical and research settings, and is the target for many therapeutic strategies, emphasizing …
clinical and research settings, and is the target for many therapeutic strategies, emphasizing …
Immunology driven by large-scale single-cell sequencing
The immune system encompasses a large degree of phenotypic diversity and plasticity in its
cell types, and more is to be uncovered. We argue that large, multiomic datasets of single …
cell types, and more is to be uncovered. We argue that large, multiomic datasets of single …
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
The Tabula Sapiens Consortium*, RC Jones… - Science, 2022 - science.org
Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …
revolutionizing cell biology and enabling new insights into the physiology of human organs …
Prenatal development of human immunity
The blood and immune systems develop in parallel during early prenatal life. Waves of
hematopoiesis separated in anatomical space and time give rise to circulating and tissue …
hematopoiesis separated in anatomical space and time give rise to circulating and tissue …