Abstract (S)-and (R)-[11 C] nicotine were synthesized by methylation of (S)-and (R)-
nornicotine using [11 C] methyl iodide. Following their intravenous injection in tracer doses …

Summary N-[methyl-11 C] nicotine (11 C-nicotine) was given intravenously to monkeys and
the uptake and regional distribution of radioactivity was followed in the brain using positron …

In order to investigate [11 C] nicotine binding and metabolism in the living human brain by
PET, routine protocols were developed for the preparation and purification of (S)-and (R)-[11 …

Abstract ABT-418 ((S)-3-methy1–5-(1-methyl-2-pyrrolidiny1) isoxazole) and N-methyl-
cytisine, high-affinity nicotinic cholinergic agonists, were labelled with 11 C and evaluated in …

Publisher Summary This chapter investigates the nicotinic receptors in the brain of monkey
and man by positron emission tomography. The topographic distribution and the …

A dual tracer model, consisting of the administration of 15 O-water and (S)-(—)-[15 C]
nicotine in close succession, is suggested to assess nicotine binding in the brain. Regional …

The autoradiographic visualisation of 90%-specific tritiated nicotine binding to slide-
mounted sections of rat brain is reported. Tritiated nicotine bound with high affinity …

Although the effects of nicotine in the brains of laboratory animals have been investigated
extensively, very little is known about its effects in the human brain. With positron emission …

Abstract [3 H] 1-Nicotine was used as a receptor ligand in the intact mouse. It was injected iv,
and radioactivity in brain regions was assayed. Nonspecific binding was estimated by …

Whole body autoradiograms of mice injected intravenously with ()nicotinemethylC14
show an initial accumulation of radioactivity in the CNS. This high concentration of nicotine …