Abstract Introduction The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD)
Prognostic and Natural History Study (PNHS) aims at understanding the role of amyloid …

Background Amyloid-β (Aβ) accumulation is considered the earliest pathological change in
Alzheimer's disease (AD). The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) …

Importance Amyloid positron emission tomography (PET) allows the direct assessment of
amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this …

Background Detecting subtle-to-moderate biomarker changes such as those in amyloid PET
imaging becomes increasingly relevant in the context of primary and secondary prevention …

Current theory suggests that β-amyloid accumulation may be an early step in the cascade
that leads to cognitive impairment in Alzheimer's disease. β-Amyloid targeted positron …

Alzheimer's disease biomarkers are becoming increasingly important for characterizing the
longitudinal course of disease, predicting the timing of clinical and cognitive symptoms, and …

Abstract Background Plasma biomarkers for Alzheimer's disease (AD) have broad potential
as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid …

In the past decade, amyloid deposition has been shown to begin many years before the
clinical symptoms of dementia in mild cognitive impairment (MCI) due to Alzheimer disease …

Purpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the
quantification of pathological amyloid deposition in the brain tissues, including the white …

Background: Amyloid-β positron emission tomography (PET) allows for in vivo detection of
fibrillar amyloid plaques, a pathologic hallmark of Alzheimer's disease (AD). However …