Trial sequential analysis in systematic reviews with meta-analysis
Background Most meta-analyses in systematic reviews, including Cochrane ones, do not
have sufficient statistical power to detect or refute even large intervention effects. This is why …
have sufficient statistical power to detect or refute even large intervention effects. This is why …
False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review
Objective Many published meta-analyses are underpowered. We explored the role of trial
sequential analysis (TSA) in assessing the reliability of conclusions in underpowered meta …
sequential analysis (TSA) in assessing the reliability of conclusions in underpowered meta …
Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods
Background Thresholds for statistical significance when assessing meta-analysis results are
being insufficiently demonstrated by traditional 95% confidence intervals and P-values …
being insufficiently demonstrated by traditional 95% confidence intervals and P-values …
Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
OBJECTIVES: To evaluate meta-analyses with trial sequential analysis (TSA). TSA adjusts
for random error risk and provides the required number of participants (information size) in a …
for random error risk and provides the required number of participants (information size) in a …
[HTML][HTML] Trial sequential analysis: novel approach for meta-analysis
H Kang - Anesthesia and pain medicine, 2021 - synapse.koreamed.org
Systematic reviews and meta-analyses rank the highest in the evidence hierarchy. However,
they still have the risk of spurious results because they include too few studies and …
they still have the risk of spurious results because they include too few studies and …
Prospective approaches to accumulating evidence
This chapter covers methods for keeping abreast of the accumulating evidence to help a
review team understand when a systematic review might need updating. This includes the …
review team understand when a systematic review might need updating. This includes the …
Statistically significant meta-analyses of clinical trials have modest credibility and inflated effects
TV Pereira, JPA Ioannidis - Journal of clinical epidemiology, 2011 - Elsevier
OBJECTIVE: To assess whether nominally statistically significant effects in meta-analyses of
clinical trials are true and whether their magnitude is inflated. STUDY DESIGN AND …
clinical trials are true and whether their magnitude is inflated. STUDY DESIGN AND …
Time to publication for results of clinical trials
S Hopewell, MJ Clarke, L Stewart… - Cochrane database …, 1996 - cochranelibrary.com
Background It has been suggested that a timelag bias exists whereby research studies with
striking results are more likely to be stopped earlier than originally planned, published …
striking results are more likely to be stopped earlier than originally planned, published …
Bias due to changes in specified outcomes during the systematic review process
JJ Kirkham, DG Altman, PR Williamson - PloS one, 2010 - journals.plos.org
Background Adding, omitting or changing outcomes after a systematic review protocol is
published can result in bias because it increases the potential for unacknowledged or post …
published can result in bias because it increases the potential for unacknowledged or post …
Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice
Objective: Heterogeneity between study results can be a problem in any systematic review
or meta-analysis of clinical trials. Identifying its presence, investigating its cause and …
or meta-analysis of clinical trials. Identifying its presence, investigating its cause and …