A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking …
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking …
Genomewide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cisregulation of BORCS7, AS3MT, and NT5C2 in the …
RRR Duarte, C Troakes, M Nolan… - American Journal of …, 2016 - Wiley Online Library
Chromosome 10q24. 32q24. 33 is one of the most robustly supported risk loci to emerge
from genomewide association studies (GWAS) of schizophrenia. However, extensive …
from genomewide association studies (GWAS) of schizophrenia. However, extensive …
Neural effects of the CSMD1 genomewide associated schizophrenia risk variant rs10503253
The single nucleotide polymorphism rs10503253 within the CUB and Sushi multiple
domains1 (CSMD1) gene on 8p23. 2 has been identified as genomewide significant for …
domains1 (CSMD1) gene on 8p23. 2 has been identified as genomewide significant for …
COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome
D Gothelf, S Eliez, T Thompson, C Hinard… - Nature …, 2005 - nature.com
Although schizophrenia is strongly hereditary, there are limited data regarding biological risk
factors and pathophysiological processes. In this longitudinal study of adolescents with …
factors and pathophysiological processes. In this longitudinal study of adolescents with …
[HTML][HTML] The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder
Schizophrenia (SZ) and bipolar disorder (BP) are highly heritable major psychiatric
disorders that share a substantial portion of genetic risk as well as their clinical …
disorders that share a substantial portion of genetic risk as well as their clinical …
The genome-wide risk alleles for psychiatric disorders at 3p21. 1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine
Z Yang, D Zhou, H Li, X Cai, W Liu, L Wang… - Molecular …, 2020 - nature.com
Schizophrenia and bipolar disorder (BPD) are believed to share clinical features, etiological
factors, and disease pathologies (such as impaired cognitive functions and dendritic spine …
factors, and disease pathologies (such as impaired cognitive functions and dendritic spine …
Biological effects of COMT haplotypes and psychosis risk in 22q11. 2 deletion syndrome
Background 22q11. 2 deletion syndrome (22q11. 2DS) is the most common genetic
syndrome associated with schizophrenia. The catechol-O-methyltransferase (COMT) gene is …
syndrome associated with schizophrenia. The catechol-O-methyltransferase (COMT) gene is …
fMRI evidence for functional epistasis between COMT and RGS4
COMT and RGS4 are promising candidate risk genes for schizophrenia1 that impact on
dopamine signaling2–4 and on prefrontal function. 5, 6 While, in general, convergent …
dopamine signaling2–4 and on prefrontal function. 5, 6 While, in general, convergent …
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We …
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Nature genetics, 2011 - nature.com
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …