In this review, we outline the role of the cholinergic system in Huntington's disease, and
briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic …

Huntington's disease (HD) is a relentless neurodegenerative disease that results in
profound disability through a triad of motor, cognitive and neuropsychiatric symptoms. At …

Trinucleotide repeat disorders are a set of genetic disorders characterized by the expansion
of certain genes of a segment of DNA that contains a repeat of three nucleotides, thus …

Recent advances in the understanding of the molecular biology and pathophysiology of
Huntington's disease have suggested new therapeutic strategies aimed at slowing …

Huntington's disease results from a polyglutamine expansion in the N-terminal region of
huntingtin (htt). This abnormality causes protein aggregation and leads to neurotoxicity …

In 1872, George Huntington, an American physician who at the time was only 22 years old,
published a short communication in the “Medical and Surgical Reporter”(Philadelphia) …

Huntington's disease (HD) is a relentlessly degenerative disorder of the central nervous
system, affecting the striatum most prominently, but also the cerebral cortex and other …

Huntington's disease is an autosomal dominantly inherited progressive neurodegenerative
disorder. The mutant gene has been localised to chromosome 4p16. 3. The gene product …

Huntington's disease (HD) is a tandem repeat disorder involving neurodegeneration and a
complex combination of symptoms. These include psychiatric symptoms, cognitive deficits …

Pathophysiology of Huntington's disease: from huntingtin fun... : Current Opinion in Neurology
Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments …