Studies were carried out to examine the effects of long-term recombinant human growth
hormone (GH) therapy on longevity in rodents. In the first study, 150 18-month-old female …

Overexpression of heterologous growth hormone (GH) in transgenic mice results in
numerous phenotypic effects, including a drastically shortened life span. Early onset of …

Although advanced age or symptoms of aging are not among approved indications for
growth hormone (GH) therapy, recombinant human GH (rhGH) and various GH-related …

The potential usefulness of growth hormone (GH) as an anti-aging therapy is of
considerable current interest. Secretion of GH normally declines during aging and …

Although age-related decline in plasma growth hormone (GH) levels is well documented,
the possible role of GH in the control of aging is controversial. Overexpression of GH in …

—It is very well documented that plasma growth hormone (GH) levels decline with age in the
human and in experimental animals, and there is considerable evidence that age-related …

In this study, we characterize transgenic mice carrying fusion genes, in which the genes
coding for human (h) or bovine (b) growth hormone (GH) have been put under the …

Mutant mice with a combined deficiency of growth hormone (GH), prolactin, and thyrotropin,
and knockout mice with GH resistance, live longer than their normal siblings. The extension …

In man, both aging and growth hormone (GH) deficiency are associated with reduced
protein synthesis, decreases in lean body mass and bone mass, and increase in body fat …

The relationship between GH and aging is poorly understood and controversial. The release
of GH normally declines with age and GH replacement therapy in the elderly has been …