Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden
of disease and mortality,–. Alcoholic hepatitis is a severe and life-threatening form of alcohol …

Low concordance between studies that examine the role of microbiota in human diseases is
a pervasive challenge that limits the capacity to identify causal relationships between host …

Chronic liver disease is rising in western countries and liver cirrhosis is the 12th leading
cause of death worldwide. Simultaneously, use of gastric acid suppressive medications is …

In recent years, several associations between common chronic human disorders and altered
gut microbiome composition and function have been reported,. In most of these reports …

Abstract Changes in the gut microbiota may underpin many human diseases, but the
mechanisms that are responsible for altering microbial communities remain poorly …

Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …

Liver cirrhosis occurs as a consequence of many chronic liver diseases that are prevalent
worldwide. Here we characterize the gut microbiome in liver cirrhosis by comparing 98 …

The human intestine, colonized by a dense community of resident microbes, is a frequent
target of bacterial pathogens. Undisturbed, this intestinal microbiota provides protection from …

To test the hypothesis that the gut microbiota of individuals with nonalcoholic fatty liver
disease (NAFLD) produce enough ethanol to be a driving force in the development and …

The mammalian gastrointestinal tract provides a complex and competitive environment for
the microbiota. Successful colonization by pathogens requires scavenging nutrients …