[HTML][HTML] Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior

MR Picciotto, MJ Higley, YS Mineur - Neuron, 2012 - cell.com
Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

[HTML][HTML] Cholinergic modulation of cortical microcircuits is layer-specific: evidence from rodent, monkey and human brain

J Obermayer, MB Verhoog, A Luchicchi… - Frontiers in neural …, 2017 - frontiersin.org
Acetylcholine (ACh) signaling shapes neuronal circuit development and underlies specific
aspects of cognitive functions and behaviors, including attention, learning, memory and …

[PDF][PDF] Cholinergic modulation of cortical function

ME Hasselmo, LM Giocomo - Journal of Molecular Neuroscience, 2006 - academia.edu
Extensive physiological research has demonstrated a number of common effects of
acetylcholine within cortical structures, including the hippocampus, piriform cortex, and …

[HTML][HTML] Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses

JM Miwa, R Freedman, HA Lester - Neuron, 2011 - cell.com
Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate
in diverse functions: reward, learning and memory, mood, sensory processing, pain, and …

Checks and balances on cholinergic signaling in brain and body function

H Soreq - Trends in neurosciences, 2015 - cell.com
A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors,
transporters, and synthesizing and degrading enzymes and regulators of their expression as …

[HTML][HTML] Cellular, synaptic and network effects of acetylcholine in the neocortex

C Colangelo, P Shichkova, D Keller… - Frontiers in neural …, 2019 - frontiersin.org
The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-
range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction …

[HTML][HTML] Cholinergic modulation of cognitive processing: insights drawn from computational models

EL Newman, K Gupta, JR Climer… - Frontiers in behavioral …, 2012 - frontiersin.org
Acetylcholine plays an important role in cognitive function, as shown by pharmacological
manipulations that impact working memory, attention, episodic memory and spatial memory …

[HTML][HTML] Illuminating the role of cholinergic signaling in circuits of attention and emotionally salient behaviors

A Luchicchi, B Bloem, JNM Viaña… - Frontiers in synaptic …, 2014 - frontiersin.org
Acetylcholine (ACh) signaling underlies specific aspects of cognitive functions and
behaviors, including attention, learning, memory and motivation. Alterations in ACh …

Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors

T Hedrick, J Waters - Journal of neurophysiology, 2015 - journals.physiology.org
The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory
perception, motor control, arousal, attention, learning, and memory. Here we investigate the …

Heterogeneity of phasic cholinergic signaling in neocortical neurons

AT Gulledge, SB Park, Y Kawaguchi… - Journal of …, 2007 - journals.physiology.org
Acetylcholine (ACh) is a neurotransmitter critical for normal cognition. Here we demonstrate
heterogeneity of cholinergic signaling in neocortical neurons in the rat prefrontal …