mTOR: Role in cancer, metastasis and drug resistance
AK Murugan - Seminars in cancer biology, 2019 - Elsevier
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …
[HTML][HTML] mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy
T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …
mTOR and cancer: insights into a complex relationship
DM Sabatini - Nature Reviews Cancer, 2006 - nature.com
Abstract mTOR (mammalian target of rapamycin) has come a long way since its humble
beginnings as a kinase of unknown function. As part of the mTORC1 and mTORC2 …
beginnings as a kinase of unknown function. As part of the mTORC1 and mTORC2 …
Current treatment strategies for inhibiting mTOR in cancer
F Chiarini, C Evangelisti, JA McCubrey… - Trends in …, 2015 - cell.com
Mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that regulates a wide range of
functions, including cell growth, proliferation, survival, autophagy, metabolism, and …
functions, including cell growth, proliferation, survival, autophagy, metabolism, and …
mTOR inhibitors in cancer therapy
YY Zaytseva, JD Valentino, P Gulhati, BM Evers - Cancer letters, 2012 - Elsevier
The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …
Targeting the mTOR signaling network in cancer
GG Chiang, RT Abraham - Trends in molecular medicine, 2007 - cell.com
The mammalian target of rapamycin (mTOR) is an unconventional protein kinase that is
centrally involved in the control of cancer cell metabolism, growth and proliferation. The …
centrally involved in the control of cancer cell metabolism, growth and proliferation. The …
[HTML][HTML] mTOR signaling in metabolism and cancer
S Huang - Cells, 2020 - mdpi.com
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a
central regulator for human physiological activity. Deregulated mTOR signaling is implicated …
central regulator for human physiological activity. Deregulated mTOR signaling is implicated …
Activating mutations of TOR (target of rapamycin)
M Hardt, N Chantaravisoot, F Tamanoi - Genes to cells, 2011 - Wiley Online Library
Mammalian target of rapamycin (mTOR) is a key regulator of eukaryotic cell growth. In
particular, mTORC1, one of the two complexes that contain mTOR, is involved in the …
particular, mTORC1, one of the two complexes that contain mTOR, is involved in the …
[HTML][HTML] Current development of the second generation of mTOR inhibitors as anticancer agents
HY Zhou, SL Huang - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, acts as a
“master switch” for cellular anabolic and catabolic processes, regulating the rate of cell …
“master switch” for cellular anabolic and catabolic processes, regulating the rate of cell …