mTOR: Role in cancer, metastasis and drug resistance

AK Murugan - Seminars in cancer biology, 2019 - Elsevier
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

[HTML][HTML] mTOR signaling in cancer and mTOR inhibitors in solid tumor targeting therapy

T Tian, X Li, J Zhang - International journal of molecular sciences, 2019 - mdpi.com
The mammalian or mechanistic target of rapamycin (mTOR) pathway plays a crucial role in
regulation of cell survival, metabolism, growth and protein synthesis in response to upstream …

[HTML][HTML] Expanding mTOR signaling

Q Yang, KL Guan - Cell research, 2007 - nature.com
The mammalian target of rapamycin (mTOR) has drawn much attention recently because of
its essential role in cell growth control and its involvement in human tumorigenesis. Great …

mTOR and cancer: insights into a complex relationship

DM Sabatini - Nature Reviews Cancer, 2006 - nature.com
Abstract mTOR (mammalian target of rapamycin) has come a long way since its humble
beginnings as a kinase of unknown function. As part of the mTORC1 and mTORC2 …

Current treatment strategies for inhibiting mTOR in cancer

F Chiarini, C Evangelisti, JA McCubrey… - Trends in …, 2015 - cell.com
Mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that regulates a wide range of
functions, including cell growth, proliferation, survival, autophagy, metabolism, and …

mTOR inhibitors in cancer therapy

YY Zaytseva, JD Valentino, P Gulhati, BM Evers - Cancer letters, 2012 - Elsevier
The mammalian target of rapamycin (mTOR) plays a key role in regulation of cellular
metabolism, growth, and proliferation. The frequent hyperactivation of mTOR signaling …

Targeting the mTOR signaling network in cancer

GG Chiang, RT Abraham - Trends in molecular medicine, 2007 - cell.com
The mammalian target of rapamycin (mTOR) is an unconventional protein kinase that is
centrally involved in the control of cancer cell metabolism, growth and proliferation. The …

[HTML][HTML] mTOR signaling in metabolism and cancer

S Huang - Cells, 2020 - mdpi.com
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a
central regulator for human physiological activity. Deregulated mTOR signaling is implicated …

Activating mutations of TOR (target of rapamycin)

M Hardt, N Chantaravisoot, F Tamanoi - Genes to cells, 2011 - Wiley Online Library
Mammalian target of rapamycin (mTOR) is a key regulator of eukaryotic cell growth. In
particular, mTORC1, one of the two complexes that contain mTOR, is involved in the …

[HTML][HTML] Current development of the second generation of mTOR inhibitors as anticancer agents

HY Zhou, SL Huang - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, acts as a
“master switch” for cellular anabolic and catabolic processes, regulating the rate of cell …