A cell's ability to recognize and adapt to the physical environment is central to its survival
and function, but how mechanical cues are perceived and transduced into intracellular …

Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and
function. In this review, we focus on advances in our understanding of how the cytoplasmic …

The fate of pluripotent mesenchymal stem cells (MSC) is determined through integration of
chemical, spatial, and physical signals. The suppression of MSC adipogenesis by …

Cells respond to the mechanical properties of the extracellular matrix (ECM) through
formation of focal adhesions (FAs), re-organization of the actin cytoskeleton and adjustment …

Bone marrow-derived mesenchymal stem and stromal cells (MSCs) are promising
candidates for cell-based therapies in diverse conditions including tissue engineering …

Recent studies have found discordant mechanosensitive outcomes when comparing 2D and
3D, highlighting the need for tools to study mechanotransduction in 3D across a wide …

Stem cells interrogate numerous microenvironmental cues, including soluble factors,
adhesive contexts, and mechanical signals, in order to mount physiologically relevant …

Exogenous mechanical forces are transmitted through the cell and to the nucleus, initiating
mechanotransductive signaling cascades with profound effects on cellular function and stem …

Stem cell behaviors are regulated by multiple microenvironmental cues. As an external
signal, mechanical stiffness of the extracellular matrix is capable of governing stem cell fate …

Stem cells in their natural microenvironment are exposed to biochemical and biophysical
cues emerging from the extracellular matrix (ECM) and neighboring cells. In particular …