[HTML][HTML] Transporter-mediated drug delivery

G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

The druggability of solute carriers

WW Wang, L Gallo, A Jadhav, R Hawkins… - Journal of medicinal …, 2019 - ACS Publications
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …

Targeting SLC transporters: small molecules as modulators and therapeutic opportunities

A Schlessinger, N Zatorski, K Hutchinson… - Trends in Biochemical …, 2023 - cell.com
Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …

SLC transporters as therapeutic targets: emerging opportunities

L Lin, SW Yee, RB Kim, KM Giacomini - Nature reviews Drug discovery, 2015 - nature.com
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

[HTML][HTML] Transporter-targeted nano-sized vehicles for enhanced and site-specific drug delivery

L Kou, Q Yao, H Zhang, M Chu, YD Bhutia, R Chen… - Cancers, 2020 - mdpi.com
Simple Summary Nano-drug delivery systems serve as Trojan horses to carry therapeutic
drugs as cargos and deliver them to target cells. The specificity of these delivery vehicles to …

[HTML][HTML] The role of solute carrier transporters in efficient anticancer drug delivery and therapy

E Puris, G Fricker, M Gynther - Pharmaceutics, 2023 - mdpi.com
Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …

Transporter-mediated drug delivery: recent progress and experimental approaches

Y Sai, A Tsuji - Drug discovery today, 2004 - Elsevier
A comprehensive list of drug transporters has recently become available as a result of
extensive genome analysis, as well as membrane physiology and molecular biology …

[HTML][HTML] Harnessing solute carrier transporters for precision oncology

MD Nyquist, B Prasad, EA Mostaghel - Molecules, 2017 - mdpi.com
Solute Carrier (SLC) transporters are a large superfamily of transmembrane carriers
involved in the regulated transport of metabolites, nutrients, ions and drugs across cellular …

[HTML][HTML] Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types

L Kou, YD Bhutia, Q Yao, Z He, J Sun… - Frontiers in …, 2018 - frontiersin.org
Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …

Membrane transporters in drug development and as determinants of precision medicine

A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …