[HTML][HTML] Transporter-mediated drug delivery
G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …
The druggability of solute carriers
The transport of materials across membranes is a vital process for all aspects of cellular
function, including growth, metabolism, and communication. Protein transporters are the …
function, including growth, metabolism, and communication. Protein transporters are the …
Targeting SLC transporters: small molecules as modulators and therapeutic opportunities
A Schlessinger, N Zatorski, K Hutchinson… - Trends in Biochemical …, 2023 - cell.com
Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across
biological membranes. Dysregulation of SLCs has been associated with various …
biological membranes. Dysregulation of SLCs has been associated with various …
SLC transporters as therapeutic targets: emerging opportunities
Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …
facilitate the transport of a wide array of substrates across biological membranes—have …
[HTML][HTML] Transporter-targeted nano-sized vehicles for enhanced and site-specific drug delivery
Simple Summary Nano-drug delivery systems serve as Trojan horses to carry therapeutic
drugs as cargos and deliver them to target cells. The specificity of these delivery vehicles to …
drugs as cargos and deliver them to target cells. The specificity of these delivery vehicles to …
[HTML][HTML] The role of solute carrier transporters in efficient anticancer drug delivery and therapy
E Puris, G Fricker, M Gynther - Pharmaceutics, 2023 - mdpi.com
Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …
Transporter-mediated drug delivery: recent progress and experimental approaches
Y Sai, A Tsuji - Drug discovery today, 2004 - Elsevier
A comprehensive list of drug transporters has recently become available as a result of
extensive genome analysis, as well as membrane physiology and molecular biology …
extensive genome analysis, as well as membrane physiology and molecular biology …
[HTML][HTML] Harnessing solute carrier transporters for precision oncology
MD Nyquist, B Prasad, EA Mostaghel - Molecules, 2017 - mdpi.com
Solute Carrier (SLC) transporters are a large superfamily of transmembrane carriers
involved in the regulated transport of metabolites, nutrients, ions and drugs across cellular …
involved in the regulated transport of metabolites, nutrients, ions and drugs across cellular …
[HTML][HTML] Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types
Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …
surface receptors or transporters could enhance the efficacy of drug delivery and therapy …
Membrane transporters in drug development and as determinants of precision medicine
A Galetin, KLR Brouwer, D Tweedie… - Nature Reviews Drug …, 2024 - nature.com
The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …
recognized. Since the initial publication from the International Transporter Consortium …