Head and neck squamous cell carcinomas (HNSCCs) are highly aggressive, multi-factorial
tumors in the upper aerodigestive tract affecting more than half a million patients worldwide …

Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of
tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and …

Background The immune response within the tumor microenvironment plays a key role in
tumorigenesis and determines the clinical outcomes of head and neck squamous cell …

Objectives In this study we describe the tumor microenvironment, the signaling pathways
and genetic alterations associated with the presence or absence of CD8+ T-cell infiltration in …

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive solid tumor, with
a 5-year mortality rate of~ 50%. The development of immunotherapies has improved the …

Head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, with low
survival rates for advanced stage tumors and minimal improvement in survival trends …

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of
malignant tumours typically caused by alcohol and tobacco consumption, although an …

Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …

Background Targeting the immune checkpoint pathway has demonstrated antitumor
cytotoxicity in treatment-refractory head and neck squamous cell carcinoma (HNSC). To …

Recent clinical trials have demonstrated a clear survival advantage in advanced head and
neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade …