Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis

AG Rowan, R Dillon, A Witkover… - Blood, The Journal …, 2020 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused
by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic …

Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype

A Marçais, L Lhermitte, M Artesi, C Laurent, K Durkin… - Leukemia, 2021 - nature.com
Adult T-cell leukemia/lymphoma (ATL) carries a poor prognosis even in indolent subtypes.
We performed targeted deep sequencing combined with mapping of HTLV-1 proviral …

The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma

LB Cook, A Melamed, H Niederer… - Blood, The Journal …, 2014 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATL) occurs in∼ 5% of human T-lymphotropic virus type 1
(HTLV-1)–infected individuals and is conventionally thought to be a monoclonal disease in …

Clonal evolution of adult T-cell leukemia/lymphoma takes place in the lymph nodes

A Umino, M Nakagawa, A Utsunomiya… - Blood, The Journal …, 2011 - ashpublications.org
Adult T-cell leukemia/lymphoma (ATLL) is the neoplasm caused by human T-cell leukemia
virus type 1 (HTLV-1). We performed oligo-array comparative genomic hybridization (CGH) …

[HTML][HTML] Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality

M Artesi, A Marçais, K Durkin, N Rosewick, V Hahaut… - Leukemia, 2017 - nature.com
Adult T-cell leukemia (ATL) is an aggressive CD4+ T-cell malignancy caused by the
oncogenic retrovirus human T-cell leukemia virus-1 (HTLV-1). 1 Although the cumulative …

HTLV-1 persistence and the oncogenesis of adult T-cell leukemia/lymphoma

CRM Bangham - Blood, The Journal of the American Society of …, 2023 - ashpublications.org
Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL)
in 5% of infected people with a decades-long latency. Charles RM Bangham reviews the …

Clonality of HTLV-1–infected T cells as a risk indicator for development and progression of adult T-cell leukemia

S Firouzi, A Farmanbar, K Nakai, M Iwanaga… - Blood …, 2017 - ashpublications.org
Adult T-cell leukemia (ATL) is an aggressive T-cell malignancy caused by human T-cell
leukemia virus type 1 (HTLV-1) that develops along a carcinogenic process involving 5 or …

Genetic profile of adult Tcell leukemia/lymphoma in Okinawa: Association with prognosis, ethnicity, and HTLV1 strains

S Sakihama, K Morichika, R Saito, M Miyara… - Cancer …, 2021 - Wiley Online Library
Genetic alterations in adult Tcell leukemia/lymphoma (ATLL), a Tcell malignancy
associated with HTLV1, and their clinical impacts, especially from the perspective of viral …

Natural course of HTLV-1 carriers with monoclonal proliferation of T lymphocytes (“pre-ATL”) in a 20-year follow-up study

Y Imaizumi, M Iwanaga, K Tsukasaki, T Hata… - Blood, 2005 - ashpublications.org
Previously we reported that asymptomatic human T-cell lymphotropic virus type 1 (HTLV-1)
carriers with a monoclonal proliferation of HTLV-1–infected T cells (“pre–adult T-cell …

[HTML][HTML] Clonal selection and evolution of HTLV-1-infected cells driven by genetic and epigenetic alteration

M Yamagishi, Y Suzuki, T Watanabe, K Uchimaru - Viruses, 2022 - mdpi.com
T cells infected with human T-cell leukemia virus type 1 (HTLV-1) acquire various
abnormalities during a long latent period and transform into highly malignant adult T-cell …