The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa

JF Linares, R Moreno, A Fajardo… - Environmental …, 2010 - Wiley Online Library
The capacity of a bacterial pathogen to produce a disease in a treated host depends on the
former's virulence and resistance to antibiotics. Several scattered pieces of evidence …

Carbon catabolite repression in Pseudomonas: optimizing metabolic versatility and interactions with the environment

F Rojo - FEMS microbiology reviews, 2010 - academic.oup.com
Metabolically versatile free-living bacteria have global regulation systems that allow cells to
selectively assimilate a preferred compound among a mixture of several potential carbon …

[HTML][HTML] Virulence and Metabolism Crosstalk: Impaired Activity of the Type Three Secretion System (T3SS) in a Pseudomonas aeruginosa Crc-Defective Mutant

T Gil-Gil, T Cuesta, S Hernando-Amado… - International Journal of …, 2023 - mdpi.com
Pseudomonas aeruginosa is a ubiquitous nosocomial opportunistic pathogen that harbors
many virulence determinants. Part of P. aeruginosa success colonizing a variety of habitats …

Metabolic regulation of antibiotic resistance

JL Martínez, F Rojo - FEMS microbiology reviews, 2011 - academic.oup.com
It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …

The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa

GA O'Toole, KA Gibbs, PW Hager… - Journal of …, 2000 - Am Soc Microbiol
The transition from a planktonic (free-swimming) existence to growth attached to a surface in
a biofilm occurs in response to environmental factors, including the availability of nutrients …

[HTML][HTML] Novel Targets of the CbrAB/Crc Carbon Catabolite Control System Revealed by Transcript Abundance in Pseudomonas aeruginosa

E Sonnleitner, M Valentini, N Wenner, FZ Haichar… - PloS one, 2012 - journals.plos.org
The opportunistic human pathogen Pseudomonas aeruginosa is able to utilize a wide range
of carbon and nitrogen compounds, allowing it to grow in vastly different environments. The …

The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

L Zhang, WC Chiang, Q Gao, M Givskov… - …, 2012 - microbiologyresearch.org
Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells
differentiate into subpopulations which display tolerance towards antimicrobial agents …

The Pseudomonas aeruginosa CreBC two-component system plays a major role in the response to β-lactams, fitness, biofilm growth, and global regulation

L Zamorano, B Moyà, C Juan, X Mulet… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Pseudomonas aeruginosa is a ubiquitous versatile environmental microorganism with a
remarkable ability to grow under diverse environmental conditions. Moreover, P. aeruginosa …

[HTML][HTML] The Transcriptional Regulator CzcR Modulates Antibiotic Resistance and Quorum Sensing in Pseudomonas aeruginosa

G Dieppois, V Ducret, O Caille, K Perron - PloS one, 2012 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa responds to zinc, cadmium and
cobalt by way of the CzcRS two-component system. In presence of these metals the …

Levels and Activity of the Pseudomonas putida Global Regulatory Protein Crc Vary According to Growth Conditions

A Ruiz-Manzano, L Yuste, F Rojo - Journal of bacteriology, 2005 - Am Soc Microbiol
The global regulatory protein Crc is involved in the repression of several catabolic pathways
for sugars, hydrocarbons, and nitrogenated and aromatic compounds in Pseudomonas …