The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and
progression of various cancers. CCL2 can activate tumour cell growth and proliferation …

The CCL2-CCR2 signaling axis has generated increasing interest in recent years due to its
association with the progression of cancer. Although first described as a chemotactic …

The CC motif chemokine ligand 2 (CCL2) is a crucial mediator of immune cell recruitment
during microbial infections and tissue damage. CCL2 is also frequently overexpressed in …

Until recently, inflammatory chemokines were viewed mainly as indispensable “gate
keepers” of immunity and inflammation. However, updated research indicates that cancer …

Chemokines are a small family of cytokines that were first discovered as chemotactic factors
in leukocytes during inflammation, and reports on the relationship between chemokines and …

Tumor cells can “hijack” chemokine networks to support tumor progression. In this context,
the CC chemokine ligand 5/CC chemokine receptor type 5 (CCL5/CCR5) axis is gaining …

Introduction Chemokines and their cognate receptors play a major role in modulating
inflammatory responses. Depending on their ligand binding, chemokine receptors can …

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory
cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is …

Within the tumor microenvironment, chemokines play a key role in immune cell trafficking
regulation and immune landscape formulation. CCL3 or macrophage inflammatory protein …

CCL4, a CC chemokine, previously known as macrophage inflammatory protein (MIP)-1β,
has diverse effects on various types of immune and nonimmune cells by the virtue of its …