Background This work evaluates the role of subtype F human immunodeficiency virus type 1
(HIV-1) protease (PR) substitutions L89M and L90M in viral replication and resistance to PR …

Objectives The purpose of this study was the qualitative and quantitative assessment of the
in vitro effect of HIV-1 protease (PR) mutation 82M on replication capacity and susceptibility …

Objectives Non-B human immunodeficiency virus (HIV)-1 subtypes possess several amino
acid signatures in the viral protease that distinguish them from subtype B, some of which are …

Objectives Relatively little is known about the development of resistance to protease
inhibitors (PIs) in non-B subtypes. In subtype B viruses, L89 is commonly found at position …

Objective: To investigate whether and how mutations at position 89 of HIV-1 protease were
associated with protease inhibitor (PI) failure, and what is the impact of the HIV-1 subtype …

The goal of this work was to compare the differences between human immunodeficiency
virus type 1 (HIV-1) of B and F1 subtypes in the acquisition of major and minor protease …

The amino acid at position 36 of the HIV-1 protease differs among various viral subtypes, in
that methionine is usually found in subtype B viruses but isoleucine is common in other …

Recent reports have shown that human immunodeficiency virus type 1 (HIV-1) Gag can
directly affect susceptibility to protease inhibitors (PIs) in the absence of known resistance …

The effect of minor mutations in PR on treatment outcome has not been well established. We
characterized the HIV protease minor mutations, L10I, compared to the minor mutation …

Population-based sequence analysis revealed the presence of a variant of human
immunodeficiency virus type 1 (HIV-1) containing an insertion of amino acid Ile in the …