Neuronal plastic rearrangements during the development and functioning of neurons are
largely regulated by trophic factors, including nerve growth factor (NGF). NGF is also …

After the discovery of the nerve growth factor (NGF) in 1952, its involvement in the regulation
of growth, differentiation, and survival of neurons was convincingly demonstrated. NGF …

The disruption of the nerve growth factor (NGF) gene in transgenic mice leads to a lethal
phenotype and hinders the study of NGF functions in the adult. In this study the phenotypic …

We earlier reported that chronic intraventricular injections of NGF into adult rats with partial
transection of the fimbria prevent the lesion-induced disappearance of cholinergic neurons …

The discovery of nerve growth factor (NGF) over 40 years ago led to the formulation of the
“Neurotrophic Factor Hypothesis”. This hypothesis states that developing neurons compete …

Publisher Summary This chapter discusses the pharmacology of nerve growth factor (NGF)
in the brain. Neurotrophic factors regulate survival and growth of neurons, suggesting that …

Nerve growth factor (NGF) is a peptide displaying multiple cholinotropic activities. The aim of
this work was to explain mechanisms of the positive and negative effects of NGF on …

Cholinergic basal forebrain (CBF) neurons have been shown to respond in vivo to
exogenous administration of NGF. Although neurotrophins and their receptors are widely …

Nerve growth factor (NGF) is a neurotrophic factor for basal forebrain cholinergic neurons
and may be of benefit in neurodegenerative diseases of humans. A method is described to …

This review provides an overview of the presence and significance of nerve growth factor
(NGF) in the central nervous system (CNS) with respect to its importance as a …