The VNTR of the AS3MT gene is associated with brain activations during a memory span task and their training-induced plasticity

W Zhao, Q Zhang, X Chen, Y Li, X Li, B Du… - Psychological …, 2021 - cambridge.org
BackgroundThe Arsenic (+ 3 oxidation state) methyltransferase (AS3MT) gene has been
identified as a top risk gene for schizophrenia in several large-scale genome-wide …

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

M Li, AE Jaffe, RE Straub, R Tao, JH Shin, Y Wang… - Nature medicine, 2016 - nature.com
Genome-wide association studies (GWASs) have reported many single nucleotide
polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking …

Functional characterization of the schizophrenia associated gene AS3MT identifies a role in neuronal development

SJ Washer, R Flynn, A OguroAndo… - American Journal of …, 2022 - Wiley Online Library
Genomewide association studies (GWAS) have identified multiple genomic regions
associated with schizophrenia, although many variants reside in noncoding regions …

Psychosis-associated DNA methylomic variation in Alzheimer's disease cortex

E Pishva, B Creese, AR Smith, W Viechtbauer… - Neurobiology of …, 2020 - Elsevier
Psychotic symptoms are a common and debilitating feature of Alzheimer's disease (AD) and
are associated with a more rapid course of decline. Current evidence from postmortem and …

Independent methylome-wide association studies of schizophrenia detect consistent case–control differences

RF Chan, AA Shabalin, C Montano… - Schizophrenia …, 2020 - academic.oup.com
Methylome-wide association studies (MWASs) are promising complements to sequence
variation studies. We used existing sequencing-based methylation data, which assayed the …

Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain

Y Takahashi, KR Maynard, M Tippani, AE Jaffe… - Molecular …, 2021 - nature.com
Genome-wide association studies have identified single nucleotide polymorphisms (SNPs)
associated with schizophrenia risk. Integration of RNA-sequencing data from postmortem …

A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density

X Cai, ZH Yang, HJ Li, X Xiao, M Li… - Schizophrenia …, 2021 - academic.oup.com
Recent advances in functional genomics have facilitated the identification of multiple genes
and isoforms associated with the genetic risk of schizophrenia, yet the causal variations …

Schizophrenia-associated differential DNA methylation in the superior temporal gyrus is distributed to many sites across the genome and annotated by the risk gene …

BC McKinney, CM Hensler, Y Wei, DA Lewis, J Wang… - medRxiv, 2020 - medrxiv.org
Background Many genetic variants and multiple environmental factors increase risk for
schizophrenia (SZ). SZ-associated genetic variants and environmental risk factors have …

Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory trainingrelated prefrontal plasticity

W Zhao, L Huang, Y Li, Q Zhang, X Chen… - Brain and …, 2020 - Wiley Online Library
Background Genetic factors have been suggested to affect the efficacy of working memory
training. However, few studies have attempted to identify the relevant genes. Methods In this …

Integration analysis of methylation quantitative trait loci and GWAS identify three schizophrenia risk variants

H Yu, W Cheng, X Zhang, X Wang, W Yue - …, 2020 - nature.com
Genome-wide association studies (GWAS) have identified hundreds of genetic variants
associated with schizophrenia (SCZ). However, prioritizing risk variants and regulatory …