[PDF][PDF] Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

[HTML][HTML] Molecular links between obesity and diabetes:“diabesity”

A Chadt, S Scherneck, HG Joost, H Al-Hasani - Endotext [Internet], 2018 - ncbi.nlm.nih.gov
Severe obesity represents a major risk factor for the development of type 2 diabetes mellitus
(T2DM). Due to the strong association of obesity and diabetes, the term “diabesity” was …

Pathophysiology of diabetes mellitus type 2: roles of obesity, insulin resistance and β-cell dysfunction

F Thévenod - Diabetes and Cancer, 2008 - karger.com
The past two decades have seen an explosive increase in the number of people diagnosed
with diabetes mellitus worldwide, particularly type 2 diabetes (T2D), which is found …

Pancreatic β-cell growth and survival–a role in obesity-linked type 2 diabetes?

MK Lingohr, R Buettner, CJ Rhodes - Trends in molecular medicine, 2002 - cell.com
Obesity-linked type 2 diabetes is a disease of insulin resistance combined with pancreatic β-
cell dysfunction. Although a role for β-cell mass in the pathogenesis of obesity-linked type 2 …

[PDF][PDF] State of the art paper Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns

GS Papaetis, P Papakyriakou… - Archives of Medical …, 2015 - termedia.pl
The prevalence of type 2 diabetes (T2D) is rapidly increasing. This is strongly related to the
contemporary lifestyle changes that have resulted in increased rates of overweight …

Mechanism linking diabetes mellitus and obesity

AS Al-Goblan, MA Al-Alfi, MZ Khan - Diabetes, metabolic syndrome …, 2014 - Taylor & Francis
Body mass index has a strong relationship to diabetes and insulin resistance. In obese
individuals, the amount of nonesterified fatty acids, glycerol, hormones, cytokines …

Obesity and the development of type 2 diabetes: the effects of fatty tissue inflammation

DP Schuster - Diabetes, metabolic syndrome and obesity: targets …, 2010 - Taylor & Francis
Obesity is a worldwide epidemic with multiple obesity-associated health problems including
type 2 diabetes, hypertension, and cardiovascular disease. Adipose tissue serves as a fuel …

Obesity in the pathogenesis of type 2 diabetes

C Day, CJ Bailey - The British Journal of Diabetes & …, 2011 - journals.sagepub.com
Obesity, and especially visceral adiposity, escalates the development of insulin resistance
and type 2 diabetes. Excess adipose tissue contributes to a chronic increase in circulating …

Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms

KD Corbin, KA Driscoll, RE Pratley, SR Smith… - Endocrine …, 2018 - academic.oup.com
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Obesity, insulin resistance, and type 2 diabetes: associations and therapeutic implications

YT Wondmkun - Diabetes, Metabolic Syndrome and Obesity, 2020 - Taylor & Francis
Obesity is a triggering factor for diabetes associated with insulin resistance. In individuals
who are obese, higher amounts of non-esterified fatty acids, glycerol, hormones, and pro …