Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

M Matsuo, T Ueno, K Monde, K Sugata… - Nature …, 2022 - nature.com
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active
antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA …

Human T-Cell Leukemia Virus Type 2 Antisense Viral Protein 2 Is Dispensable for In Vitro Immortalization but Functions To Repress Early Virus Replication In Vivo

H Yin, P Kannian, N Dissinger, R Haines… - Journal of …, 2012 - Am Soc Microbiol
Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are closely related but
pathogenically distinct human retroviruses. The antisense strand of the HTLV-1 genome …

The nature of the HTLV-1 provirus in naturally infected individuals analyzed by the viral DNA-capture-seq approach

H Katsuya, S Islam, BJY Tan, J Ito, P Miyazato… - Cell Reports, 2019 - cell.com
The retrovirus human T-cell leukemia virus type 1 (HTLV-1) integrates into the host DNA,
achieves persistent infection, and induces human diseases. Here, we demonstrate that viral …

Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis

N Rosewick, K Durkin, M Artesi, A Marcais… - Nature …, 2017 - nature.com
Human T-cell leukaemia virus type-1 (HTLV-1) and bovine leukaemia virus (BLV) infect T-
and B-lymphocytes, respectively, provoking a polyclonal expansion that will evolve into an …

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

C Nicot, M Dundr, JM Johnson, JR Fullen, N Alonzo… - Nature medicine, 2004 - nature.com
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-
specific host immune response, and causes adult T-cell leukemia and lymphoma in …

Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein

CJ Cáceres, J Angulo, F Lowy, N Contreras… - Nucleic Acids …, 2018 - academic.oup.com
The human T-cell leukemia virus type 1 (HTLV-1), a member of the Retroviridae family, was
the first retrovirus to be associated with a disease in humans. After a prolonged latency …

A novel therapeutic molecule against HTLV-1 infection targeting provirus

A Tanaka, S Takeda, R Kariya, K Matsuda, E Urano… - Leukemia, 2013 - nature.com
Human T-cell leukemia virus type I (HTLV-1) is a retrovirus that causes adult T-cell leukemia
(ATL) and the neurological disorder, HTLV-1-associated myelopathy, in humans. 1–3 HTLV …

[HTML][HTML] Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1

MR Billman, D Rueda, CRM Bangham - Wellcome open research, 2017 - ncbi.nlm.nih.gov
Background: The human leukaemia virus HTLV-1 expresses essential accessory genes that
manipulate the expression, splicing and transport of viral mRNAs. Two of these genes, tax …

Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated …

M Halin, E Douceron, I Clerc, C Journo… - Blood, The Journal …, 2009 - ashpublications.org
Human T-cell leukemia virus type 1 (HTLV-1) and type 2 (HTLV-2) retroviruses infect T
lymphocytes. The minus strand of the HTLV-1 genome encodes HBZ, a protein that could …

Permissive sense and antisense transcription from the 5′ and 3′ long terminal repeats of human T-cell leukemia virus type 1

S Laverdure, N Polakowski, K Hoang… - Journal of …, 2016 - Am Soc Microbiol
IMPORTANCE The chromosomally integrated form of the retrovirus human T-cell leukemia
virus type 1 (HTLV-1) contains identical DNA sequences, known as long terminal repeats …