Background Trauma is a heterogeneous condition, and specific clinical phenotypes may
identify target populations that could benefit from certain treatment strategies. In this …

Introduction The current shortage of accurate and readily available, validated biomarkers of
disease severity in sepsis is an important limitation when attempting to stratify patients into …

Background The gut microbiome plays a pivotal role in the progression of sepsis. However,
the specific mechanism of gut microbiota and its metabolites involved in the process of …

Background Understanding temporal patterns of organ dysfunction (OD) may aid early
recognition of complications after trauma and assist timing and modality of treatment …

Abstract Introduction PROWESS (Recombinant Human Activated Protein C Worldwide
Evaluation in Severe Sepsis) was a phase III, randomized, double blind, placebo controlled …

Objective Community-acquired pneumonia (CAP) is the primary cause of death for children
under five years of age globally. Hence, it is essential to investigate new early biomarkers …

Background Altered coagulation and alveolar injury are the hallmarks of acute respiratory
distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology …

Introduction The innate immune response to trauma hemorrhage involves inflammatory
mediators, thus promoting cellular dysfunction as well as cell death in diverse tissues. These …

Background Sepsis is a highly heterogeneous syndrome, which has hindered the
development of effective therapies. This has prompted investigators to develop a precision …

Background Acute lung injury (ALI) is a major cause of acute respiratory failure with high
mortality despite lung-protective ventilation. Prior work has shown disordered inflammation …