Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain
RNA splicing is a key mechanism linking genetic variation with psychiatric disorders.
Splicing profiles are particularly diverse in brain and difficult to accurately identify and …
Splicing profiles are particularly diverse in brain and difficult to accurately identify and …
Replication of brain function effects of a genome-wide supported psychiatric risk variant in the CACNA1C gene and new multi-locus effects
S Erk, A Meyer-Lindenberg, DEJ Linden, T Lancaster… - Neuroimage, 2014 - Elsevier
Variation in the CACNA1C gene has consistently been associated with psychosis in
genome wide association studies. We have previously shown in a sample of n= 110 healthy …
genome wide association studies. We have previously shown in a sample of n= 110 healthy …
CACNA1C: association with psychiatric disorders, behavior, and neurogenesis
AL Moon, N Haan, LS Wilkinson… - Schizophrenia …, 2018 - academic.oup.com
Large-scale genome-wide association studies have consistently shown that genetic
variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit …
variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit …
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …
Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans
DT Dao, PB Mahon, X Cai, CE Kovacsics… - Biological …, 2010 - Elsevier
BACKGROUND:: Recent genome-wide association studies have associated polymorphisms
in the gene CACNA1C, which codes for Cav1. 2, with a bipolar disorder and depression …
in the gene CACNA1C, which codes for Cav1. 2, with a bipolar disorder and depression …
The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general …
J Strohmaier, M Amelang, LA Hothorn, SH Witt… - Molecular …, 2013 - nature.com
Genome-wide association studies have reported an association between the A-allele of
rs1006737 within CACNA1C and affective disorders and schizophrenia. The aim of the …
rs1006737 within CACNA1C and affective disorders and schizophrenia. The aim of the …
Genetic variation in CACNA1C affects brain circuitries related to mental illness
Context TheCACNA1Cgene (α-1C subunit of the L-type voltage-gated calcium channel) has
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …
been identified as a risk gene for bipolar disorder and schizophrenia, but the mechanism of …
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons
T Yoshimizu, JQ Pan, AE Mungenast, JM Madison… - Molecular …, 2015 - nature.com
Psychiatric disorders have clear heritable risk. Several large-scale genome-wide
association studies have revealed a strong association between susceptibility for psychiatric …
association studies have revealed a strong association between susceptibility for psychiatric …
CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population
BackgroundCommon psychiatric disorders are highly heritable, indicating that genetic
factors play an important role in their aetiology. The CACNA1C gene, which codes for …
factors play an important role in their aetiology. The CACNA1C gene, which codes for …
Hippocampal and frontolimbic function as intermediate phenotype for psychosis: evidence from healthy relatives and a common risk variant in CACNA1C
S Erk, A Meyer-Lindenberg, P Schmierer, S Mohnke… - Biological …, 2014 - Elsevier
Background Variation in CACNA1C has consistently been associated with psychiatric
disease in genome-wide association studies. We have previously shown that healthy …
disease in genome-wide association studies. We have previously shown that healthy …