Gut microbial β-glucuronidases (gmβ-GUS) played crucial roles in regulating a variety of
endogenous substances and xenobiotics on the circulating level, thus had been recognized …

Gut bacterial β-glucuronidases (GUS) play an important role in deconjugation of various O-
glucuronides, which are tightly linked with the drug-induced intestinal toxicity. Increasing …

Bacterial β-glucuronidases play key roles in the deconjugation of a variety of endogenous
and drug glucuronides, thus have been recognized as important targets to modulate the …

Intestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of
various glucuronides into free aglycone, have been recognized as key targets for treating …

Gut microbial β-glucuronidases (GUSs) inhibition is a new approach for managing some
diseases and medication therapy. However, the structural and functional complexity of GUSs …

Gut microbial β-glucuronidases show varied substrate specificity and inhibition propensity,
highlighting the necessity of discovering broad-spectrum β-glucuronidase inhibitor to meet …

Abstract β-Glucuronidase plays a vital role in the metabolism of drugs and endogenous
substance. Herein, we assayed the inhibitory effects of thirty-six flavonoids (1–36) toward β …

Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic
circulation-triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced …

Gut microbial β-glucuronidases have drawn much attention due to their role as a potential
therapeutic target to alleviate some drugs or their metabolites-induced gastrointestinal …

The human gastrointestinal (GI) tract plays an important role in disease and health. The
overexpression of β-glucuronidase, an enzyme produced in the gastrointestinal tract, has …