NPY Y2 receptor agonist PYY (3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice
R Moriya, T Shirakura, H Hirose, T Kanno, J Suzuki… - Peptides, 2010 - Elsevier
Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor
of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be …
of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be …
Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice
L Wang, G Gourcerol, PQ Yuan… - American Journal …, 2010 - journals.physiology.org
Peptide YY (PYY) antisecretory effect on intestinal epithelia is well established, whereas
less is known about its actions to influence colonic motility in conscious animals. We …
less is known about its actions to influence colonic motility in conscious animals. We …
The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y2 receptor: pharmacological evidence and molecular cloning
M Goumain, T Voisin, AM Lorinet, R Ducroc… - Molecular …, 2001 - ASPET
A peptide YY (PYY)-preferring receptor [PYY> neuropeptide Y (NPY)] was previously
characterized in rat small intestinal crypt cells, where it mediates inhibition of fluid secretion …
characterized in rat small intestinal crypt cells, where it mediates inhibition of fluid secretion …
Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY (3–36) on food …
CR Abbott, CJ Small, AR Kennedy, NM Neary, A Sajedi… - Brain research, 2005 - Elsevier
The gastrointestinal-derived hormone peptide YY (PYY) is released from intestinal L-cells
post-prandially in proportion to calorie intake, and modulates food intake. Peripheral …
post-prandially in proportion to calorie intake, and modulates food intake. Peripheral …
Role of peptide YY (3–36) in the satiety produced by gastric delivery of macronutrients in rats
R Reidelberger, A Haver… - American Journal of …, 2013 - journals.physiology.org
Peptide YY (3–36)[PYY (3–36)] is postulated to act as a hormonal signal from gut to brain to
inhibit food intake. PYY (3–36) potently reduces food intake when administered systemically …
inhibit food intake. PYY (3–36) potently reduces food intake when administered systemically …
Peptide YY: a neuroendocrine neighbor of note
HM Cox - Peptides, 2007 - Elsevier
Endocrine cells, enteric neurons and enterocytes provide an integrated functional defense
against luminal factors, including nutrients, microbes and toxins. Prominent among intrinsic …
against luminal factors, including nutrients, microbes and toxins. Prominent among intrinsic …
Structure−Activity Studies Including a Ψ(CH2-NH) Scan of Peptide YY (PYY) Active Site, PYY(22−36), for Interaction with Rat Intestinal PYY Receptors …
A Balasubramaniam, Z Tao, W Zhai… - Journal of medicinal …, 2000 - ACS Publications
Peptide YY (PYY) is a gut hormone that inhibits secretion and promotes absorption and
growth in the intestinal epithelium. We have performed structure− activity studies with the …
growth in the intestinal epithelium. We have performed structure− activity studies with the …
PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones
JRC Parkinson, WS Dhillo, CJ Small… - American Journal …, 2008 - journals.physiology.org
Peptide YY (PYY) is secreted postprandially from the endocrine L cells of the gastrointestinal
tract. PYY3-36, the major circulating form of the peptide, is thought to reduce food intake in …
tract. PYY3-36, the major circulating form of the peptide, is thought to reduce food intake in …
Antisecretory mechanisms of peptide YY in rat distal colon
EE Whang, OJ Hines, JR Reeve, D Grandt… - Digestive diseases and …, 1997 - Springer
Peptide YY (PYY) is a potent regulator ofintestinal secretion. These studies investigated
therole of Y1 and Y2 receptor subtypes in mediating theantisecretory effects of PYY on …
therole of Y1 and Y2 receptor subtypes in mediating theantisecretory effects of PYY on …
Peptide YY (3–36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys
Peptide YY3–36 [PYY (3–36)], a gastrointestinal peptide that is released into the circulation
in response to ingesting a meal, has recently been suggested to play a role in controlling …
in response to ingesting a meal, has recently been suggested to play a role in controlling …