Low-dose methoxyflurane analgesia in adolescent patients with moderate-to-severe trauma pain: a subgroup analysis of the STOP! study

S Hartshorn, P Dissmann, F Coffey… - Journal of Pain …, 2019 - Taylor & Francis
Introduction The undertreatment of acute pain presents a significant challenge in the
Emergency Department. This post hoc subgroup analysis of a previously reported …

Methoxyflurane analgesia in adult patients in the emergency department: a subgroup analysis of a randomized, double-blind, placebo-controlled study (STOP!)

F Coffey, P Dissmann, K Mirza, M Lomax - Advances in therapy, 2016 - Springer
Introduction Acute pain remains highly prevalent in the Emergency Department (ED) setting.
This double-blind, randomized, placebo-controlled UK study investigated the efficacy and …

Efficacy and safety of inhaled low-dose methoxyflurane for acute paediatric pain: a systematic review

S Hartshorn, PM Middleton - Trauma, 2019 - journals.sagepub.com
Introduction Undertreatment of acute, moderate-to-severe pain in children is common, due in
part to barriers to the use of opioids. Low-dose methoxyflurane is an inhaled, non-opioid …

Inhaled methoxyflurane (Penthrox®) versus placebo for injury-associated analgesia in children—the MAGPIE trial (MEOF-002): study protocol for a randomised …

S Hartshorn, MJ Barrett, MD Lyttle, SA Yee, AT Irvine… - Trials, 2019 - Springer
Background Pain from injuries is one of the commonest symptoms in children attending
emergency departments (EDs), and this is often inadequately treated in both the pre-hospital …

STOP!: a randomised, double-blind, placebo-controlled study of the efficacy and safety of methoxyflurane for the treatment of acute pain

F Coffey, J Wright, S Hartshorn, P Hunt… - Emergency Medicine …, 2014 - emj.bmj.com
Objective To evaluate the short-term efficacy and safety of methoxyflurane for the treatment
of acute pain in patients presenting to an emergency department (ED) with minor trauma …

Does inhaled methoxyflurane implement fast and efficient pain management in trauma patients? A systematic review and meta-analysis

H Liu, X Fu, YF Ren, SY Tan, SR Xiang, C Zheng… - Pain and Therapy, 2021 - Springer
Introduction Evidence on the use of inhaled methoxyflurane in the management of trauma
pain is conflicting and obfuscated. This study aimed to determine the efficacy and safety of …

Clinical assessment and risk stratification for prehospital use of methoxyflurane versus standard analgesia in adult patients with trauma pain

H Zaki, S Türkmen, A Azad, K Bashir… - Turkish Journal of …, 2023 - journals.lww.com
Oligoanalgesia, the undertreatment of trauma-related pain using standard analgesics in
prehospital and emergency departments, has been extensively documented as one of the …

Low-dose methoxyflurane versus standard of care analgesics for emergency trauma pain: A systematic review and meta-analysis of pooled data

A Fabbri, AM Borobia, A Ricard-Hibon… - Journal of Pain …, 2021 - Taylor & Francis
Purpose Undertreatment of trauma-related pain is common in the pre-hospital and hospital
settings owing to barriers to the use of traditional standard of care analgesics. Low-dose …

The role of inhaled methoxyflurane in acute pain management

KM Porter, AD Dayan, S Dickerson… - Open Access …, 2018 - Taylor & Francis
Methoxyflurane is an inhaled analgesic administered via a disposable inhaler which has
been used in Australia for over 40 years for the management of pain associated with trauma …

[HTML][HTML] Inhaled methoxyflurane provides greater analgesia and faster onset of action versus standard analgesia in patients with trauma pain: InMEDIATE: a …

AM Borobia, SG Collado, CC Cardona… - Annals of emergency …, 2020 - Elsevier
Study objective The objective of the InMEDIATE study was to evaluate the change in
intensity of traumatic pain over the first 20 min in adult patients treated with methoxyflurane …