Background & Aims: Intrahepatic vascular resistance is regulated in part by the
vasoconstricting and relaxing effects of compounds such as endothelin and nitric oxide …

Background/Aim: Portal hypertension is characterized by splanchnic hyperemia due to a
reduction in mesenteric vascular resistance. Mediators of this hyperemia include nitric oxide …

Increased intrahepatic resistance in cirrhotic livers is in part caused by increased vascular
tone. Several morphological abnormalities have been described in the sinusoidal …

Indirect evidence exists implicating vascular nitric oxide in the pathogenesis of arterial
vasodilation in cirrhosis. In the current study, a coincubation assay to estimate the vascular …

Nitric oxide (NO) is postulated to mediate the peripheral arterial vasodilation in cirrhosis.
However, it is not known which isoform of the nitric oxide synthase (NOS) is involved in the …

Nitric oxide (NO) is postulated to play a role in the pathogenesis of arterial vasodilation in
chronic portal hypertension. This present study investigates the relationship between …

The mechanisms that regulate vascular resistance in the liver are an area of active
investigation. Previously, we have shown that nitric oxide (NO) modulates hepatic vascular …

Portal hypertension (PHT) is characterized by splanchnic hyperemia caused by a reduction
in mesenteric vascular resistance. Mediators of this hyperemia include nitric oxide (NO). This …

This study investigated whether nitric oxide (NO) plays a role in the intrahepatic portal
circulation in normal rat livers perfused in situ. N omega-nitro-L-arginine (NNA), a specific …

Reduced production of nitric oxide (NO) in the cirrhotic liver results from a defect in hepatic
endothelial cell nitric oxide synthase (ecNOS) and appears to contribute to the high …