Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …

Endochondral ossification is the process by which the embryonic cartilaginous model of
most bones contributes to longitudinal growth and is gradually replaced by bone. During …

The skeletal elements of the axial and appendicular skeleton are preformed as cartilage
templates by a mechanism called endochondral ossification. During this process, a cartilage …

Three transcription factors of the Sox family have essential roles in different steps of the
chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is …

Chondrogenesis is the earliest phase of skeletal development, involving mesenchymal cell
recruitment and migration, condensation of progenitors, and chondrocyte differentiation, and …

Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

The formation of bone is a continual process in vertebrate development, initiated during fetal
development and persisting in adulthood in the form of remodeling and repair. The …

In mammals, most skeletal elements are formed through endochondral bone formation,
which is characterized by the initial formation of cartilage molds from mesenchymal …

The endochondral bones of the skeleton develop from a cartilage template and grow via a
process involving a cascade of chondrocyte differentiation steps culminating in formation of …

During endochondral ossification bones are formed as cartilage templates in which
chondrocytes proliferate, differentiate into hypertrophic chondrocytes and are gradually …