Imaging of Tauopathies with PET Ligands: State of the Art and Future Outlook

M Conte, MS De Feo, MMA Sidrak, F Corica, J Gorica… - Diagnostics, 2023 - mdpi.com
(1) Background: Tauopathies are a group of diseases characterized by the deposition of
abnormal tau protein. They are distinguished into 3R, 4R, and 3R/4R tauopathies and also …

Tau imaging in neurodegenerative diseases using positron emission tomography

YT Wang, P Edison - Current neurology and neuroscience reports, 2019 - Springer
Abstract Purpose of Review Abnormal accumulation of tau protein is the main hallmark of
tauopathies and is closely associated with neurodegeneration and cognitive impairment …

The tauopathies: Neuroimaging characteristics and emerging experimental therapies

KJ Riley, BD Graner, MC Veronesi - Journal of Neuroimaging, 2022 - Wiley Online Library
The tauopathies are a heterogeneous group of neurodegenerative disorders in which the
prevailing underlying disease process is intracellular deposition of abnormal misfolded tau …

Tau imaging with PET: an overview of challenges, current progress, and future applications.

JS Robertson, CC Rowe… - The Quarterly Journal of …, 2017 - europepmc.org
Folded and misfolded tau is common to many neurodegenerative conditions, collectively
termed" tauopathies". In recent years, many efforts have contributed toward development of …

Development of tau PET imaging ligands and their utility in preclinical and clinical studies

Y Choi, S Ha, YS Lee, YK Kim, DS Lee… - Nuclear medicine and …, 2018 - Springer
The pathological features of Alzheimer's disease are senile plaques which are aggregates
of β-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are …

[PDF][PDF] Tau positron emission tomography in tauopathies: A narrative review

H Lee, Y Gu, SW Seo, SH Moon - Precision and Future Medicine, 2023 - pfmjournal.org
Aggregation of misfolded tau in the brain is a major pathological feature common in various
neurodegenerative disorders known as tauopathies, including Alzheimer's disease …

Tau PET and tauopathies

K Herholz - European Journal of Nuclear Medicine and Molecular …, 2016 - Springer
PET tracers for pathological deposits of tau protein aggregates in the brain are currently
undergoing rapid development. They are targeting pathological deposits of tau aggregates …

[引用][C] [ICP178]: HEADTOHEAD IN VIVO COMPARISON OF TAUSPECIFIC PET TRACERS IN ALZHEIMER's DISEASE: [11C]THK5351 VERSUS [11C]PBB3 …

K Chiotis, P Stenkrona, O Almkvist… - Alzheimer's & …, 2017 - Wiley Online Library
Background During the past five years, the development of tau-specific PET tracers has
enabled the visualization of tau deposits in Alzheimer's disease (AD) as well as other …

Disclosing tau tangles using PET imaging: a pharmacological review of the radiotracers available in 2021

É Van Wambeke, T Gérard, R Lhommel… - Acta Neurologica …, 2022 - Springer
Neurological symptoms depend on the topography of the lesions in the nervous system,
hence the importance of brain imaging for neurologists. Neurological treatment, however …

The development and validation of tau PET tracers: current status and future directions

N Okamura, R Harada, A Ishiki, A Kikuchi… - Clinical and translational …, 2018 - Springer
Purpose To provide an overview on positron emission tomography (PET) imaging of tau
pathology in Alzheimer's disease (AD) and other neurodegenerative disorders. Results …