Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …

Hepatic fibrosis is a woundhealing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Hepatic fibrosis : Current Opinion in Gastroenterology Hepatic fibrosis : Current Opinion in
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Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Liver fibrosis is caused by many chronic diseases. Liver injury results in activation of
collagenproducing cells and excessive deposition of extracellular matrix proteins. This …

Tremendous insights into the understanding of hepatic fibrosis have taken place over the
past ten years. Foremost among these is the recognition that hepatic stellate cells (formerly …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

The last decade has seen a rapid expansion in our understanding of the mechanisms
leading to hepatic stellate cell activation. The classic activation pathway of initiation …