The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

There is a large body of evidence that the liver microcirculation has to be considered as a
major target in hepatic ischemia/reperfusion injury. The nature of microvascular injury, which …

Sepsis causes significant alterations in the hepatic macroand microcirculation. Diverging
views exist on global hepatic blood flow during experimental sepsis because of the large …

The vasculature plays a critical role in multiple physiologic and pathophysiologic processes.
A number of recent advances have led to renewed focus on the vasculature in the liver. In …

The Hepatic circulation is unique among vascular beds. The most obvious unique features
include the dual vascular supply; the mechanism of intrinsic regulation of the hepatic artery …

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

The factors that regulate blood flow through the hepatic microvascular system and their
relation to hepatic structure and function are poorly under~ tood.'-~ Although some …

This review highlights recent advances in our understanding of mechanisms underlying
reperfusion injury to the liver after warm hepatic ischemia. Sinusoidal endothelial cells and …

The liver is believed to play a major role in the initiation of multiorgan failure, the most lethal
complication in the clinical course of sepsis. Microbes and their virulence factors enter the …

Liver ischemia/reperfusion (IR) injury is typified by an inflammatory response.
Understanding the cellular and molecular events underpinning this inflammation is …