Potential of therapeutic small molecules in apoptosis regulation in the treatment of neurodegenerative diseases: An updated review

HG Dailah - Molecules, 2022 - mdpi.com
Neurodegenerative disorders (NDs) include Parkinson's disease (PD), Alzheimer's disease
(AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the common …

Treating neurodegenerative conditions through the understanding of neuronal apoptosis

SR D'Mello, PC Chin - Current Drug Targets-CNS & …, 2005 - ingentaconnect.com
Neurological diseases disrupt the quality of the lives of patients and often leads to their
premature deaths. A common feature of most neurological diseases is the degeneration of …

Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases

V Cavallucci, M D'Amelio - Current pharmaceutical design, 2011 - ingentaconnect.com
Neurodegenerative diseases that include amyotrophic lateral sclerosis, Huntington's
disease, Alzheimer's disease, Parkinson's disease, stroke, brain trauma and spinal cord …

Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases

FX Sureda, F Junyent, E Verdaguer… - Current …, 2011 - ingentaconnect.com
The purpose of this review is to discuss potential pathways involved in the pathogenesis of
neurodegenerative diseases, highlighting current pharmacological drug targets in neuronal …

Cell death targets and potential modulators in Alzheimer's disease

RE Castro, M MM Santos, P MC Gloria… - Current …, 2010 - ingentaconnect.com
Apoptosis is now recognized as a normal feature in the development of the nervous system
and may also play a role in neurodegenerative disorders, such as Alzheimer's disease. Cell …

Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches.

A Camins, M Pallas, JS Silvestre - Methods and findings in …, 2008 - europepmc.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most significant
neurodegenerative disorders in the developed world. However, although these diseases …

Apoptosis and its therapeutic implications in neurodegenerative diseases

NS Erekat - Clinical Anatomy, 2022 - Wiley Online Library
Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis

A Camins, E Verdaguer, J Folch… - Current drug …, 2007 - ingentaconnect.com
Over the last few decades, understanding of the mechanisms involved in the process of
neuronal cell death has grown. Recent findings have established that DNA damage, and …

Cell death, inflammation and oxidative stress in neurodegenerative diseases: mechanisms and cytoprotective molecules

A Vejux - International Journal of Molecular Sciences, 2021 - mdpi.com
Neurodegenerative diseases are the most common chronic neurological pathologies
associated with age, with a major impact on the patient's quality of life. These pathologies …

Neuronal apoptosis in neurodegenerative diseases: from basic research to clinical application

P Kermer, J Liman, JH Weishaupt, M Bähr - Neurodegenerative …, 2004 - karger.com
In recent years, the investigation of erroneous regulation of apoptotic mechanisms during
acute and chronic injury of neuronal cells has gained increasing attention. Besides acute …