Diacylglycerol lipases (DGLs) mainly catalyze “on-demand” biosynthesis of bioactive
monoacylglycerols (MAGs) with different long fatty acyl chains, including 2 …

The diacylglycerol lipases (DAGLs) hydrolyse diacylglycerol to generate 2-
arachidonoylglycerol (2-AG), the most abundant ligand for the CB1 and CB2 cannabinoid …

The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-
1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide …

Diacylglycerol lipase-α (DAGL-α) is an intracellular, multidomain protein responsible for the
formation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the central nervous …

An understanding of how conformational dynamics modulates function and catalysis of
human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate …

Lipase from Aspergillus oryzae (AOL) was experimentally identified to be strictly specific for
mono-and diacylglycerol, but not triacylglycerol, whose substrate selectivity was …

DDHD2 has been reported to exhibit phospholipase A1, triacylglycerol (TG) lipase and
diacylglycerol (DG) lipase activities. However, the detailed enzymatic properties of DDHD2 …

Diacylglycerol lipases (DAGLs) are the most important enzymes for the biosynthesis of the
endocannabinoid 2-arachidonoylglycerol (2-AG), and their role in various …

Diacylglycerol lipase (DAGL)-α and-β are enzymes responsible for the biosynthesis of the
endocannabinoid 2-arachidonoylglycerol (2-AG). Selective and reversible inhibitors are …

Diacylglycerol (DG) lipase, which hydrolyses 1-stearoyl-2-arachidonyl-sn-glycerol to
produce an endocannabinoid, 2-arachidonoylglycerol, was purified from the soluble fraction …