Loss of myogenic potential and fusion capacity of muscle stem cells isolated from contractured muscle in children with cerebral palsy

AA Domenighetti, MA Mathewson… - … of Physiology-Cell …, 2018 - journals.physiology.org
Cerebral palsy (CP) is the most common cause of pediatric neurodevelopmental and
physical disability in the United States. It is defined as a group of motor disorders caused by …

Reduced satellite cell population may lead to contractures in children with cerebral palsy

LR Smith, HG Chambers… - … Medicine & Child …, 2013 - Wiley Online Library
Aim Satellite cells are the stem cells residing in muscle responsible for skeletal muscle
growth and repair. Skeletal muscle in cerebral palsy (CP) has impaired longitudinal growth …

[HTML][HTML] Ex vivo adult stem cell characterization from multiple muscles in ambulatory children with cerebral palsy during early development of contractures

M Corvelyn, J Meirlevede, J Deschrevel, E Huyghe… - Differentiation, 2023 - Elsevier
Cerebral palsy (CP) is one of the most common conditions leading to lifelong childhood
physical disability. Literature reported previously altered muscle properties such as lower …

Reduced satellite cell number in situ in muscular contractures from children with cerebral palsy

S Dayanidhi, PB Dykstra, V Lyubasyuk… - Journal of …, 2015 - Wiley Online Library
Satellite cells (SC) are quiescent adult muscle stem cells critical for postnatal development.
Children with cerebral palsy have impaired muscular growth and develop contractures …

Does a reduced number of muscle stem cells impair the addition of sarcomeres and recovery from a skeletal muscle contracture? A transgenic mouse model

S Dayanidhi, MC Kinney, PB Dykstra… - … and Related Research …, 2020 - journals.lww.com
Background Children with cerebral palsy have impaired muscle growth and muscular
contractures that limit their ROM. Contractures have a decreased number of serial …

[HTML][HTML] Muscle microbiopsy to delineate stem cell involvement in young patients: a novel approach for children with cerebral palsy

M Corvelyn, N De Beukelaer, R Duelen… - Frontiers in …, 2020 - frontiersin.org
Cerebral palsy (CP), the single largest cause of childhood physical disability, is
characterized firstly by a lesion in the immature brain, and secondly by musculoskeletal …

Skeletal muscle satellite cells: mediators of muscle growth during development and implications for developmental disorders

S Dayanidhi, RL Lieber - Muscle & nerve, 2014 - Wiley Online Library
Satellite cells (SCs) are the muscle stem cells responsible for longitudinal and cross
sectional postnatal growth and repair after injury and which provide new myonuclei when …

[HTML][HTML] Muscle contracture and passive mechanics in cerebral palsy

RL Lieber, J Fridén - Journal of applied physiology, 2019 - journals.physiology.org
Skeletal muscle contractures represent the permanent shortening of a muscle-tendon unit,
resulting in loss of elasticity and, in extreme cases, joint deformation. They may result from …

Differential DNA methylation and transcriptional signatures characterize impairment of muscle stem cells in pediatric human muscle contractures after brain injury

LA Sibley, N Broda, WR Gross, AF Menezes… - The FASEB …, 2021 - Wiley Online Library
Limb contractures are a debilitating and progressive consequence of a wide range of upper
motor neuron injuries that affect skeletal muscle function. One type of perinatal brain injury …

Satellite cells as players and targets in normal and diseased muscle

A Bornemann, F Maier, R Kuschel - Neuropediatrics, 1999 - thieme-connect.com
Satellite cells (SC), also termed adult myoblasts, are mononuclear cells of myogenic
lineage. They are attached to the muscle fiber plasma membrane and surrounded by a …