Clinical biology of the pituitary adenoma

S Melmed, UB Kaiser, MB Lopes, J Bertherat… - Endocrine …, 2022 - academic.oup.com
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

Pituitary tumor pathogenesis

I Shimon, S Melmed - The Journal of Clinical Endocrinology & …, 1997 - academic.oup.com
Pituitary tumors are mostly benign monoclonal adenomas arising from adenohypophyseal
cells in the anterior pituitary. These tumors usually autonomously express and secrete …

Pathogenesis of pituitary tumors

S Melmed - Nature Reviews Endocrinology, 2011 - nature.com
Pituitary adenomas may hypersecrete hormones (including prolactin, growth hormone and
adrenocorticotropic hormone, and rarely follicle-stimulating hormone, luteinizing hormone or …

Mechanisms of disease: the pathogenesis of pituitary tumors

S Ezzat, SL Asa - Nature Clinical Practice Endocrinology & Metabolism, 2006 - nature.com
Pituitary tumors exhibit a spectrum of biology, with variable growth and hormonal behaviors.
They therefore provide an opportunity to examine pathogenetic mechanisms that underlie …

The pathogenesis of pituitary tumors

SL Asa, S Ezzat - Annual Review of Pathology: Mechanisms of …, 2009 - annualreviews.org
Recently there has been significant progress in our understanding of pituitary development,
physiology, and pathology. New information has helped to clarify the classification of …

Epidemiology and etiopathogenesis of pituitary adenomas

ED Aflorei, M Korbonits - Journal of neuro-oncology, 2014 - Springer
Pituitary adenomas are usually benign monoclonal tumours presenting either due to
hypersecretion of pituitary hormones, and/or due to local space occupying effects and …

Novel insights into pituitary tumorigenesis: genetic and epigenetic mechanisms

V Srirangam Nadhamuni, M Korbonits - Endocrine reviews, 2020 - academic.oup.com
Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …

Molecular defects in the pathogenesis of pituitary tumours

A Levy, S Lightman - Frontiers in Neuroendocrinology, 2003 - Elsevier
The majority of pituitary adenomas are trophically stable and change relatively little in size
over many years. A comparatively small proportion behave more aggressively and come to …

Landscape of genomic alterations in pituitary adenomas

WL Bi, P Horowitz, NF Greenwald, M Abedalthagafi… - Clinical Cancer …, 2017 - AACR
Purpose: Pituitary adenomas are the second most common primary brain tumor, yet their
genetic profiles are incompletely understood. Experimental Design: We performed whole …

Clinicopathological correlations in pituitary adenomas

O Mete, SL Asa - Brain pathology, 2012 - Wiley Online Library
Pituitary adenomas are common neuroendocrine neoplasms arising from adenohypophysial
cells. Recent progress in our understanding of pituitary tumorigenesis as well as pathways …